Targeted Neuromodulation for Contamination-Based OCD

This study is looking into a new way to treat obsessive-compulsive disorder (OCD), specifically for people who have contamination and washing symptoms. Current OCD treatments often use a "one size fits all" approach, but this study aims to personalize treatment. Researchers are testing two types of transcranial magnetic stimulation (TMS) called cTBS and iTBS, along with a sham (inactive) stimulation. They want to see if these treatments can reduce your contamination/washing symptoms by changing how certain brain regions communicate. You might be able to join if you are 18-55 years old, have an OCD diagnosis, and your main OCD symptoms involve contamination. The study will measure changes in brain connectivity after 6 weeks to see if the treatments are successful. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 50 participants. It will compare two types of active brain stimulation (cTBS and iTBS) against a sham (inactive) stimulation.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome of the study is measured at 6 weeks after treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05048251

Individually Targeted Neuromodulation for Contamination-based OCD

Recruiting
NAAges 18–55InterventionalTreatment
Mclean Hospital
~50 participants
Updated 2024-03-15 on ClinicalTrials.gov
What's tested:cTBSiTBSsham

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Functional connectivity between R MFG and brain regions within VAN (expressed as a Z-score)
Measured over 6 weeks
Obsessive-Compulsive Disorder
1 sites across 1 states
Massachusetts1
  • Brian P Brennan, MD · PRINCIPAL_INVESTIGATOR · Mclean Hospital

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  • Functional connectivity between R MFG and brain regions within VAN (expressed as a Z-score)6 weeks

    Change in functional connectivity between: 1) R MFG and right temporoparietal junction (R TPJ); 2) R MFG and left temporoparietal junction (L TPJ); 3) R MFG and right inferior frontal gyrus (R IFG); 4) R MFG and left inferior frontal gyrus (L IFG); 5) R MFG and right anterior insula (R AI); 6) R MFG and left anterior insula (L AI); 7) R MFG and right posteromedial putamen; and 8) R MFG and left posteromedial putamen