Targeted Neuromodulation for Contamination-Based OCD
This study is looking into a new way to treat obsessive-compulsive disorder (OCD), specifically for people who have contamination and washing symptoms. Current OCD treatments often use a "one size fits all" approach, but this study aims to personalize treatment. Researchers are testing two types of transcranial magnetic stimulation (TMS) called cTBS and iTBS, along with a sham (inactive) stimulation. They want to see if these treatments can reduce your contamination/washing symptoms by changing how certain brain regions communicate. You might be able to join if you are 18-55 years old, have an OCD diagnosis, and your main OCD symptoms involve contamination. The study will measure changes in brain connectivity after 6 weeks to see if the treatments are successful. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 50 participants. It will compare two types of active brain stimulation (cTBS and iTBS) against a sham (inactive) stimulation.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary outcome of the study is measured at 6 weeks after treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Individually Targeted Neuromodulation for Contamination-based OCD
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Brian P Brennan, MD · PRINCIPAL_INVESTIGATOR · Mclean Hospital
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Functional connectivity between R MFG and brain regions within VAN (expressed as a Z-score)6 weeks
Change in functional connectivity between: 1) R MFG and right temporoparietal junction (R TPJ); 2) R MFG and left temporoparietal junction (L TPJ); 3) R MFG and right inferior frontal gyrus (R IFG); 4) R MFG and left inferior frontal gyrus (L IFG); 5) R MFG and right anterior insula (R AI); 6) R MFG and left anterior insula (L AI); 7) R MFG and right posteromedial putamen; and 8) R MFG and left posteromedial putamen