Back to search results

DISE: Understanding Obstruction Patterns in Sleep Apnea

This study is for adults with obstructive sleep apnea (OSA) who are looking for alternatives to CPAP and are already scheduled for a drug-induced sleep endoscopy (DISE) procedure. DISE is a way to look at your upper airway while you're in a sleep-like state. Researchers want to better understand what causes airway blockage during sleep. They will use special catheters to measure airway pressures (Pharyngeal Manometry) and ultrasound to look at soft tissues in your airway (Submental Ultrasound) during your DISE. The goal is to identify how your airway collapses to help predict if upper airway surgery might work for you. The study aims to enroll 241 participants, but its current status is unclear.

Study design
This is an interventional study planning to enroll 241 participants. It is not specified if it's randomized or blinded.
What's involved
You will undergo Pharyngeal Manometry and Submental Ultrasound during your clinically indicated DISE procedure. Your response to potential surgery will be measured within one year of joining the study.
Compensation
Not stated in the trial record.
Follow-up
Your response to upper airway surgery will be measured within one year of enrollment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05050383

DISE: Phenotyping Obstruction Patterns

Recruiting
NAAges 18+InterventionalBasic science
University of Pennsylvania
~241 participants
Updated 2025-08-13 on ClinicalTrials.gov
What's tested:Pharyngeal ManometrySubmental Ultrasound

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify the pathogenic determinants of airway obstruction at specific sites of pharyngeal collapse by characterizing upper airway pressure-flow/area relationships during DISE to predict responses to upper airway surgery
Measured over Within 1 year of enrollment

Conditions

Obstructive Sleep Apnea

Explore related trials

Obstructive Sleep Apnea

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Raj C Dedhia, MD, MSCR · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Everett Seay
[email protected]
2156158777
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Exclusion

None

What this trial measures

  • Identify the pathogenic determinants of airway obstruction at specific sites of pharyngeal collapse by characterizing upper airway pressure-flow/area relationships during DISE to predict responses to upper airway surgeryWithin 1 year of enrollment

    Change in pre-operative to post-operative AHI