PPMI Online: Understanding Parkinson's Disease

PPMI Online is an observational study that collects information from people with and without Parkinson's disease (PD). The goal is to better understand what puts someone at risk for PD and what factors predict its development. This study is part of a larger effort, the Parkinson Progression Marker Initiative, which aims to find markers that show how PD is changing over time. These markers could then be used in future studies to test new treatments that might slow down or stop the progression of PD. Researchers will be looking at how your Parkinson's symptoms change over a long period, up to 240 months (20 years). The study is currently recruiting, and they plan to enroll up to 500,000 participants. You can join if you are 18 years or older, with or without a diagnosis of Parkinson's disease.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It aims to enroll up to 500,000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 240 months (20 years) to assess changes in their Parkinson's symptoms.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05065060

Parkinson Progression Marker Initiative Online (PPMI Online)

Recruiting
Not specifiedAges 18+Observational
Michael J. Fox Foundation for Parkinson's Research
~500,000 participants
Updated 2026-09-08 on ClinicalTrials.gov
What's tested:Observation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Unified Parkinson's Disease Rating Scale Ib & II
Measured over Baseline to 240 months
Parkinson Disease

NCT05065060

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UCSF Movement Disorders and Neuromodulation Center (MDNC)

    San Francisco, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Caroline Tanner, MD, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
  • Kenneth L Marek, MD · PRINCIPAL_INVESTIGATOR · Institute for Neurodegenerative Disorders
University of California, San Francisco
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Parkinson Disease (PD) Participants:
Male or female age 18 years or older.
Has received a diagnosis of Parkinson's disease
Male or female age 18 years or older.
Has not received a diagnosis of Parkinson's disease
  • Unified Parkinson's Disease Rating Scale Ib & IIBaseline to 240 months

    Evaluates self-reported motor and nonmotor Parkinson's disease symptoms