Back to search results

Understanding Motivation in Parkinson's Patients with Percept DBS

This study aims to understand how motivation and decision-making are affected in people with Parkinson's disease who have a Medtronic Percept or RC+S Deep Brain Stimulation (DBS) device. You could be eligible if you have Parkinson's disease or Dystonia, have had your DBS device implanted for over a month, and do not have severe memory problems (MoCA score below 20). Participants will play computer games that involve making decisions, sometimes with their DBS device on and sometimes with it off. Researchers will measure how many risky decisions you make and how quickly you react. The study is currently unclear about its recruitment status and plans to enroll 70 participants.

Study design
This interventional study plans to enroll 70 participants. It compares your behavior when your Percept DBS device is on versus when it's off.
What's involved
You will play decision-making games on a computer application in both clinic and home settings. These sessions will occur with your DBS on and off, and neural activity will be recorded.
Compensation
Not stated in the trial record.
Follow-up
Your data will be collected starting from admission and can be analyzed for up to three years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05065151

Understanding Motivation in Parkinson's Patients Through Neurophysiology

Recruiting
NAAges 18+InterventionalBasic science
University of California, San Francisco
~70 participants
Updated 2026-06-05 on ClinicalTrials.gov
What's tested:Stimulation onStimulation offDecision Making Task

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent of Risky Decisions made with Percept DBS stimulation on for Parkinson's Disease Patients
Measured over The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years
+10 more outcomes measured

Conditions

Parkinson Disease
Deep Brain Stimulation
Motivation

Explore related trials

DystoniaParkinson Disease

NCT05065151

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of California San Francisco

    San Francisco, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Simon J Little, MBBS, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Sarah Wang, PhD
[email protected]
415-353-7885
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Has Parkinson's Disease or Dystonia
Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN
Has DBS device implanted either bilaterally or unilaterally
Male or female
More than 1 month post-DBS surgery

Exclusion

Severe cognitive impairments
Has MOCA score below 20
Pregnancy
Age less than 18 years old

What this trial measures

  • Percent of Risky Decisions made with Percept DBS stimulation on for Parkinson's Disease PatientsThe values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years

    Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

  • Percent of Risky Decisions made with Percept DBS stimulation off for Parkinson's Disease PatientsThe values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years

    Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

  • Reaction Time During Decision-Making TaskThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    The investigators will measure the time it takes for patients to make each decision on the value-based decision-making task in the clinic.

  • Task Success RateThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    The investigators will calculate the percentage of trials in which patients complete the task successfully according to predefined task performance criteria.

  • Acceptance Rate of Risky Versus Safe OptionsThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    The proportion of trials where patients accept risky versus safe options will be calculated and compared across stimulation ON and OFF conditions.

  • Force Exertion During Motor ResponsesThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    Force data will be recorded during motor responses to evaluate physical engagement and motor control during task performance.

  • Low frequency local field potentialsThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    Local field potentials (LFPs) will be recorded from the implanted Percept device to evaluate neural activity during decision making under different stimulation conditions. Low frequency power will be calculated during specific time intervals during the task. Cardiac artifact will be removed with electrocardiogram (ECG) measurements recorded during the same task.

  • Electroencephalogram (EEG) theta band powerThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average theta band power will be calculated in specific time intervals during the task.

  • Electroencephalogram (EEG) beta band powerThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average beta band power will be calculated in specific time intervals during the task.

  • Electroencephalogram (EEG) gamma band powerThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average gamma band power will be calculated in specific time intervals during the task.

  • Electroencephalogram (EEG) alpha band powerThe values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

    Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average alpha band power will be calculated in specific time intervals during the task.