This study is looking at CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy), a genetic disorder that affects small blood vessels and can lead to strokes and dementia. Researchers want to understand how CADASIL develops and changes over time by observing people with the condition. They will use MRI (magnetic resonance imaging) scans to look at blood vessels. The study aims to understand the disease's progression through detailed medical evaluations and studies of blood and urine samples. You may be able to join if you are an adult aged 18 or older with CADASIL, or a healthy volunteer. The study's success will be measured by how well it helps researchers understand the disease's development over 13 years. The current recruitment status is unclear.

Study design

This is an observational study, meaning participants will be monitored over time without receiving new treatments. It plans to enroll up to 110 individuals with CADASIL and up to 45 healthy control subjects.

What's involved

You would have 4 study visits over 9 years, each lasting 6-8 hours per day for 2-4 days. You would provide blood and urine samples, have an electrocardiogram (ECG) to check your heart's electrical activity, and complete a family tree.

Compensation

Not stated in the trial record.

Follow-up

The primary goal of understanding the disease's development will be measured at 13 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.