This observational study is looking into the connection between obesity in midlife and the risk of developing Alzheimer's disease. Researchers want to understand the underlying processes that link high body fat to Alzheimer's. You may be eligible if you are between 40 and 60 years old, have normal thinking and memory abilities (MMSE score of 25 or higher, or a Clinical Dementia Rating Scale of 0), and are willing to undergo MRI and PET scans. The PET scans will involve injections of radioactive tracers, [11C]PiB and 18F-AV-1451 (Flortaucipir), to look at brain changes. The study aims to see if there's increased brain shrinkage (atrophy) in people with obesity compared to those without. The study's current status is unclear.

Study design

This is an observational study planning to enroll 240 participants. It is not testing a specific intervention or drug.

What's involved

Participants will undergo MRI and PET scans, including injections of radioactive tracers. Metabolic tests like oral glucose tolerance, fasting plasma insulin, glucose, and hemoglobin A1c measurements will also be performed.

Compensation

Not stated in the trial record.

Follow-up

Brain atrophy will be measured at 10 hours after certain procedures, but overall follow-up duration is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.