WBSI Guided Personalized Delivery of TTFields for Glioblastoma

This study is for people with Glioblastoma (GBM), a type of brain tumor, who are starting treatment with Optune. Optune uses electrical fields (called Tumor Treating Fields or TTFields) to fight cancer. This research aims to see if a more precise way of mapping the Optune device onto your head, using advanced MRI scans called "whole brain spectroscopy imaging," works better than the standard mapping method. To join, you must be at least 22 years old, have a confirmed GBM diagnosis, and have already had surgery and radiation therapy. The main goal is to see how long it takes for the tumor to grow or spread, measured every two months. The study is currently recruiting 155 participants, but its overall status is unclear.

Study design
This is an interventional study planning to enroll 155 participants. It compares two ways of mapping the Optune device for Glioblastoma patients.
What's involved
All participants will receive whole brain spectroscopy imaging as part of their MRI scans. Participants will either receive standard Optune mapping or an alternative, more precise mapping.
Compensation
Not stated in the trial record.
Follow-up
The study measures how long it takes for the tumor to progress, with assessments every two months.

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NCT05086497

WBSI Guided Personalized Delivery of TTFields

Recruiting
NAAges 22+InterventionalDiagnostic
Abramson Cancer Center at Penn Medicine
~155 participants
Updated 2026-08-06 on ClinicalTrials.gov
What's tested:Whole Brain Spectroscopy Imaging Array Mapping Layout

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Time to Progression
Measured over 2 month intervals
GBM
Glioma Glioblastoma Multiforme
Tumor, Brain
2 sites across 1 states
Pennsylvania2
  • Suyash Mohan, MD, PDCC · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
  • Sanjeev Chawla, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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Eligibility criteria

Inclusion

Adult population ≥ 22 years
Histologically confirmed diagnosis of GBM or molecular GBM according to c-IMPACT NOW criteria
Have undergone maximal safe surgical resection followed by either standard full course radiation of 6000 cGy in 6 weeks or a hypofractionated course of 4000 cGy in 3 weeks
3 Harboring any genotype profiles (MGMT promoter methylation or unmethylation and/or isocitrate dehydrogenase (IDH) mutant or IDH wild-type)
Possessing adequate hematological, hepatic and renal functions
Willingness to receive TTFields

Exclusion

Presence of infra-tentorial GBM
Pregnancy
Significant co-morbidities at baseline which would prevent maintenance TMZ treatment
Active implanted medical device, a skull defect (such as missing bone with no replacement) or bullet fragments. Examples of active electronic devices include deep brain stimulators, spinal cord stimulators, vagus nerve stimulators,pacemakers, defibrillators and programmable shunts. , other implanted electronic devices in the brain.
Sensitivity to conductive hydrogels like the gel used on electrocardiogram (ECG) stickers or transcutaneous electrical nerve stimulation (TENS) electrodes.
Presence of significant hemorrhage in and around the tumor bed that may potentially degrade the image quality.
  • Time to Progression2 month intervals

    Using whole brain spectroscopy imaging, diffusion and perfusion MR imaging, a combined multiparametric approach will be utilized to compare treatment response from patients enrolled in two study arms.