18F-DOPA PET/MRI for Focal Hyperinsulinism

This study is looking at a special imaging test called 18F-Fluoro Dopa PET/MRI to help find the exact spot in the pancreas causing hyperinsulinism (low blood sugar due to too much insulin). This test uses a small amount of a radioactive tracer (18F-DOPA) to create detailed pictures. The goal is to see how well this imaging can pinpoint the problem area before surgery, especially for patients who haven't responded to medications like diazoxide or octreotide. If you have confirmed hyperinsulinism and your current medications aren't working, you might be able to join this study. The main goal is to make this imaging test more available and to see how accurate it is in guiding treatment.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 100 participants.
What's involved
Participants will undergo an 18F-Fluoro Dopa PET/MRI imaging study of their pancreas.
Compensation
Not stated in the trial record.
Follow-up
The study aims to increase access to the imaging for patients with hyperinsulinism who failed medical therapy, measured at one year.

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NCT05088798

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

Recruiting
PHASE2All AgesInterventionalDiagnostic
Washington University School of Medicine
~100 participants
Updated 2025-12-19 on ClinicalTrials.gov
What's tested:18F-Fluoro Dopa PET/MRI Imaging

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Increase Access to 18F-DOPA PET/MRI (or PET/CT) for patients with HI who failed medical therapy
Measured over one year
Hyperinsulinism
1 sites across 1 states
Missouri1
  • Ana Maria Arbelaez, MD, MSCI · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

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  • Increase Access to 18F-DOPA PET/MRI (or PET/CT) for patients with HI who failed medical therapyone year

    To provide access to 18F-DOPA PET/MRI (or PET/CT) for patients with HI who do not respond to pharmacological therapy and are being considered for pancreatic surgery. We will measure this by totaling the number of scans performed yearly.