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NCT05092100

Neural Mechanisms for Reducing Interference During Episodic Memory Formation

Enrolling by Invitation
NAAges 18–80InterventionalBasic science
University of Oregon
~737 participants
Updated 2024-09-19 on ClinicalTrials.gov
What's tested:Visual stimulus similarityfMRIEye tracking

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Behavior
Measured over Data will be collected over a 5 year period. Results from sub-studies will be analyzed within 6 months of the conclusion of data collection.
+2 more outcomes measured

Conditions

Behavior

Explore related trials

BehaviorHealthy VolunteersMemory

Where it's being run

1 sites across 1 states
Oregon1

Study leadership

  • Brice A Kuhl, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Oregon

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

healthy and between the ages of 18-35 years old
native English speakers
right-handed.
healthy and between the ages of 18-80 years old
native English speakers
right-handed.

Exclusion

For some sub-studies, individuals older than age 35 will be excluded because of potential differences in cognitive and brain function across age groups that are beyond the scope of the proposed studies.
Individuals will be informed that use of psychoactive drugs, mental health disorders, and chronic or temporary sleep deficits (an average of less than 6 hours of sleep over the past month or less than 4 hours of sleep the night prior to the experimental session) are reasons for exclusion because of the potential influence on cognitive functioning.

What this trial measures

  • BehaviorData will be collected over a 5 year period. Results from sub-studies will be analyzed within 6 months of the conclusion of data collection.

    Behavioral responses will be recorded by keyboard or external button boxes. These responses will be used to assess the accuracy with which participants remember individual images. Accuracy will be averaged across stimuli within each learning condition to obtain measures of mean memory accuracy (i.e., the percentage of stimuli that were successfully remembered) per condition and participant.

  • fMRI pattern similarityData will be collected over a 5 year period. Results from sub-studies will be analyzed within 6 months of the conclusion of data collection.

    fMRI will be used to measure hemodynamic (BOLD) responses as participants study images. Pattern similarity analyses will be applied to the fMRI data. Pattern similarity will be indexed by the correlation (r) between patterns of BOLD activity. Pattern similarity will be computed for images within and across different learning conditions.

  • eye trackingData will be collected over a 5 year period. Results from sub-studies will be analyzed within 6 months of the conclusion of data collection.

    Eye tracking equipment will be used to measure gaze direction and fixations as participants study images. These data will be used to calculate variables such as the number of saccades (eye movements) made and the percentage of time (within each trial) spent looking at each portion of an image. Data from individual trials will be averaged across trials within each learning condition. This will yield mean values per condition and participant.