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Cerebellar Stimulation for Aphasia Rehabilitation After Stroke

This study is testing if a treatment called cathodal Cerebellar tDCS (transcranial direct current stimulation), which uses gentle electrical stimulation on the right side of the brain, can help people with aphasia (language problems) recover better after a stroke. This is combined with a language therapy called Semantic Feature Analysis (SFA). Researchers want to see if this combination improves naming ability more than SFA alone. You might be able to join if you are 18 or older, had a stroke in the left side of your brain at least 6 months ago, speak English, and have aphasia with naming difficulties. The main goal is to see how much your ability to name pictures improves. The current status of this study is unclear, and it plans to enroll 60 participants.

Study design
This interventional study plans to enroll 60 participants. It compares cathodal Cerebellar tDCS combined with Semantic Feature Analysis (SFA) to a sham (inactive) device combined with SFA.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your naming accuracy will be measured one week after the end of the SFA treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05093673

Cerebellar Stimulation for Aphasia Rehabilitation

Recruiting
NAAges 18–99InterventionalTreatment
Johns Hopkins University
~60 participants
Updated 2026-03-20 on ClinicalTrials.gov
What's tested:Cathodal Cerebellar tDCSSemantic Feature Analysis (SFA)Sham

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in accuracy of naming untrained pictures (Philadelphia Naming Test)
Measured over Pre-treatment to one week after the end of SFA treatment

Conditions

Stroke

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Stroke

NCT05093673

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Johns Hopkins Hospital

    Baltimore, Marylandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Rajani Sebastian, PhD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Rajani Sebastian, PhD
[email protected]
410-502-2445
Email the study team

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Eligibility criteria

Inclusion

Chronic ischemic or hemorrhagic left hemisphere stroke
Fluent speaker of English by self-report
Age 18 or older
6 months post onset of stroke
Diagnosis of aphasia and naming impairment using the Western Aphasia Battery-Revised

Exclusion

Lesion in the right cerebellum
Previous neurological disorder (other than stroke) affecting the brain, or any other neurodegenerative disorder or psychiatric disorder
Seizures during the previous 6 months
Uncorrected visual loss or hearing loss by self-report
Use of medications that lower the seizure threshold (e.g., methylphenidate)
Use of N-methyl-D-aspartate (NMDA) antagonists (e.g., memantine)
History of brain surgery or any metal in the head
Severely impaired auditory comprehension (lower than 2 on the Comprehension subscore on the Western Aphasia Battery-Revised)
Severely limited verbal output (lower than 2 on the Spontaneous Speech rating scale on the Western Aphasia Battery-Revised)
Individuals with severe claustrophobia, cardiac pacemakers or ferromagnetic implants, and pregnant women will be excluded from the MRI portion of the study.

What this trial measures

  • Change in accuracy of naming untrained pictures (Philadelphia Naming Test)Pre-treatment to one week after the end of SFA treatment

    Behavioral measure of change in untrained naming. Scores ranges from 0 to 175 with higher scores meaning better naming ability.