This study is looking at whether a medication called methylprednisolone (a steroid often used to reduce inflammation) can help people recover from total knee replacement surgery (total knee arthroplasty or TKA) more comfortably. Researchers want to see if taking methylprednisolone starting the day after surgery reduces pain, opioid use, and nausea, and improves how well you can move your knee compared to a placebo (a sugar pill). You might be able to join if you are at least 18 years old, are having your first total knee replacement for osteoarthritis, and haven't used certain medications long-term. The study aims to enroll 420 participants, but its current recruitment status is unclear.

Study design

This is an interventional study comparing methylprednisolone to a placebo in 420 planned participants.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Opioid consumption will be measured at one week postoperative. Pain and functional outcomes will be assessed at 3 and 6 weeks postoperatively.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.