Back to search results

Fasting and the Immune System in Healthy Adults

This study is looking at how a short period of fasting affects the immune system in healthy adults. Researchers will ask you to eat your usual diet for two days, followed by one 36-hour period where you only drink water (up to 2 liters per day). During this time, your blood sugar will be monitored to make sure you stay safe. The study will then look at changes in your immune cells (peripheral blood mononuclear cells) to see if fasting alters your immune system. They hope to understand if fasting can change how your immune system works. This study is currently unclear on its recruitment status and plans to enroll 4 participants.

Study design
This is an interventional study with an unclear status, planning to enroll 4 healthy adult male participants.
What's involved
You would follow a controlled diet for two days, then fast for 36 hours while drinking only water and having your blood sugar monitored.
Compensation
Not stated in the trial record.
Follow-up
Changes in your immune cells will be measured at 7 months after the fasting period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05104502

Immunomodulatory Effects of Fasting in Healthy Adults

Recruiting
NAAges 20–40InterventionalBasic science
University of California, Davis
~4 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:Dietary Fasting

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in peripheral blood mononuclear cells
Measured over 7 months

Conditions

Fasting

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
California1

Who to contact

Antonio Ji
[email protected]
916-551-2630
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Age: 20-40 years, to constitute a young study population
Gender: male subjects, to control for gender differences
BMI: 19-27 kg/m2 to constitute a normal/healthy weight population
Weight: 120 lbs or more
Fasting glucose: 70-100 mg/dL, to ensure that fasting can be tolerated without inducing dangerously low levels of blood glucose
Subjects must be willing to undergo a period of 36 hours of water-only fasting
Subjects must be willing to collect samples of each bowel movement produced throughout the entire study period for microbiome analysis
Subjects must be willing to collect blood pricks for blood glucose levels using a Contour Next One Blood Glucose Testing Kit during the fasting stage of the study protocol.

Exclusion

Current smoking
Anemia
Pregnancy or current breastfeeding
Chronic diseases including diabetes mellitus, thyroid disease, metabolic syndrome, cancer, or previous cardiovascular events
Gastrointestinal diseases including irritable bowel syndrome, Crohn's disease, ulcerative colitis, celiac disease
Consumption of \>1 alcoholic drink/day
Extreme dietary or exercise patterns
Recent weight fluctuations (greater than 10% in the last six months)
Regular use of over-the-counter allergy or pain medications (\>1/week)
Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones
Use of hormonal birth control including oral contraception pills, hormonal IUDs or rings, or hormonal birth control patches

What this trial measures

  • Changes in peripheral blood mononuclear cells7 months

    Changes in surface proteins and glycoproteins of peripheral blood mononuclear cells