Behavioral Interventions for Eating Habits in Overweight and Obesity

This study is looking at how two different behavioral interventions, called Active Implicit Priming and Control Implicit Priming, affect brain responses to food, eating habits, and body weight in people who are overweight or have obesity. You could be eligible if you are between 18 and 65 years old and have a BMI (Body Mass Index) of 27 or higher. We are trying to see if these 10-minute interventions, along with a Food Exposure Task, can change how your brain reacts to food and improve your eating behaviors. Success will be measured by changes in brain activity when seeing food, how you rate food images, and how much food you eat over 12 weeks. The current status of this study is unclear, but it plans to enroll 228 participants.

Study design
This study is an interventional study planning to enroll 228 participants. It compares two behavioral interventions: Active Implicit Priming and Control Implicit Priming.
What's involved
You would participate in approximately 10-minute behavioral interventions and a 10-30 minute Food Exposure Task. Brain activity and food intake will be measured at the beginning and after 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed for 12 weeks after the start of the study.

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NCT05107908

Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

Recruiting
NAAges 18–65Interventional
University of Colorado, Denver
~228 participants
Updated 2026-02-12 on ClinicalTrials.gov
What's tested:Active Implicit PrimingControl Implicit PrimingFood Exposure Task

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging
Measured over Baseline, 12 weeks
+2 more outcomes measured
Overweight and Obesity
1 sites across 1 states
Colorado1
  • Jason Tregellas, PhD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

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Eligibility criteria

Inclusion

18-65 years old
BMI of 27 or greater

Exclusion

MRI contraindications (e.g., metal or electronic devices in the body)
Pregnancy
  • Percent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance ImagingBaseline, 12 weeks

    Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex.

  • Change in Food Image RatingsBaseline, 12 weeks

    Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat.

  • Change in Food IntakeBaseline, 12 weeks

    Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal.