Understanding Fear and Anxiety with Deep Brain Stimulation and Virtual Reality

This study aims to understand how the brain creates fear and anxiety, especially in conditions like PTSD (Post-Traumatic Stress Disorder) and GAD (Generalized Anxiety Disorder). You could be eligible if you are 18 to 70 years old, can read and write English, and have already had acute depth or chronic responsive neurostimulation (RNS) electrodes placed in your brain. Participants will complete tasks on a computer, some using a virtual reality headset, which will show different fear-provoking images. During these tasks, researchers will measure your brain activity, heart rate, and skin perspiration (sweat). The goal is to see how these physiological changes, like eye-blinks, heart rate variability, and skin conductance, are affected by the tasks, both with and without Deep Brain Stimulation. The study is currently unclear on its recruitment status and plans to enroll 80 people.

Study design
This interventional study plans to enroll 80 participants. It is not specified if the study is randomized or blinded.
What's involved
You will complete tasks on a computer, some using a virtual reality headset, while researchers measure your brain activity, heart rate, and skin perspiration.
Compensation
Not stated in the trial record.
Follow-up
Physiological changes will be measured during the intervention/behavioral tasks with and without stimulation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05120635

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

Recruiting
NAAges 18–70InterventionalBasic science
Duke University
~80 participants
Updated 2026-08-31 on ClinicalTrials.gov
What's tested:Deep Brain StimulationVirtual and augmented reality tasks

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Physiological change - eye-blinks
Measured over during the intervention/behavioral tasks with and without stimulation
+3 more outcomes measured
Fear
GAD
Emotional Memory
PTSD
2 sites across 2 states
California1
North Carolina1
  • Nanthia Suthana, PhD · PRINCIPAL_INVESTIGATOR · Duke Health

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

18 years of age or older
Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
Willing to provide informed consent and participate in the study
Ability to read and write English fluently

Exclusion

Unwilling to provide informed consent
Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement
Pregnant women
Participants with active psychosis
Participants with suicidal ideation
Participants with substance abuse issues
  • Physiological change - eye-blinksduring the intervention/behavioral tasks with and without stimulation

    Eye blinks will be measured using an eye tracking device and will be measure in blinks per second.

  • Physiological change - heart rate variabilityduring the intervention/behavioral tasks with and without stimulation

    heart rate variability will be measured in milliseconds.

  • Physiological change - skin conductanceduring the intervention/behavioral tasks with and without stimulation

    Skin conductance will be measured in microSiemens.

  • Neurophysiological activityduring the intervention/behavioral tasks with and without stimulation

    Neurophysiological activity will be measured in Hz