Understanding Fear and Anxiety with Deep Brain Stimulation and Virtual Reality
This study aims to understand how the brain creates fear and anxiety, especially in conditions like PTSD (Post-Traumatic Stress Disorder) and GAD (Generalized Anxiety Disorder). You could be eligible if you are 18 to 70 years old, can read and write English, and have already had acute depth or chronic responsive neurostimulation (RNS) electrodes placed in your brain. Participants will complete tasks on a computer, some using a virtual reality headset, which will show different fear-provoking images. During these tasks, researchers will measure your brain activity, heart rate, and skin perspiration (sweat). The goal is to see how these physiological changes, like eye-blinks, heart rate variability, and skin conductance, are affected by the tasks, both with and without Deep Brain Stimulation. The study is currently unclear on its recruitment status and plans to enroll 80 people.
- Study design
- This interventional study plans to enroll 80 participants. It is not specified if the study is randomized or blinded.
- What's involved
- You will complete tasks on a computer, some using a virtual reality headset, while researchers measure your brain activity, heart rate, and skin perspiration.
- Compensation
- Not stated in the trial record.
- Follow-up
- Physiological changes will be measured during the intervention/behavioral tasks with and without stimulation.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
At a glance
Conditions
Where it's being run
2 sites across 2 statesStudy leadership
- Nanthia Suthana, PhD · PRINCIPAL_INVESTIGATOR · Duke Health
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Physiological change - eye-blinksduring the intervention/behavioral tasks with and without stimulation
Eye blinks will be measured using an eye tracking device and will be measure in blinks per second.
- Physiological change - heart rate variabilityduring the intervention/behavioral tasks with and without stimulation
heart rate variability will be measured in milliseconds.
- Physiological change - skin conductanceduring the intervention/behavioral tasks with and without stimulation
Skin conductance will be measured in microSiemens.
- Neurophysiological activityduring the intervention/behavioral tasks with and without stimulation
Neurophysiological activity will be measured in Hz