This study, called PediDOSE, aims to improve how paramedics treat seizures in children on ambulances. Currently, many children still have seizures when they arrive at the emergency room. This might be because the medicine, midazolam, is not given in the right dose or quickly enough. This study compares two ways paramedics give midazolam: a new, standardized protocol using only intramuscular (IM) or intranasal (IN) midazolam with age-based doses, versus the usual protocol that varies by ambulance agency. The study will look at whether children are still seizing when they arrive at the emergency department. Children aged 6 months to 13 years who are actively seizing, under paramedic care, and transported by a participating ambulance agency can join, unless they have a benzodiazepine allergy, are pregnant, or have severe growth restriction.

Study design

This interventional study plans to include 6,700 participants. It compares a standardized seizure protocol with a conventional seizure protocol.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary outcome, seizing on emergency department arrival, is measured between arrival and 10 minutes after arrival.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.