Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity
This study aims to understand why young people who lose weight often regain it when they return to a regular diet, and if hormones play a role. Participants aged 11 to 15 with a BMI over 30 (obesity) will take part. You cannot join if you've had bariatric surgery or recently used anti-obesity medications. The study involves an 8-week period of meal replacement therapy (shakes and frozen meals) and lifestyle counseling, followed by a longer observation period. Researchers will measure changes in fat regain and hormones like ghrelin and gastric inhibitory polypeptide after 17 weeks to see if the intervention is successful. The study plans to enroll 260 participants, but its current status is unclear.
- Study design
- This is an interventional study with 260 planned participants. It involves a meal replacement and lifestyle modification intervention.
- What's involved
- You would participate for up to 35 weeks, including an 8-week meal replacement period and bi-weekly lifestyle counseling sessions.
- Compensation
- Not stated in the trial record.
- Follow-up
- Changes in fat mass regain and hormones are measured at 17 weeks after initial weight loss.
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Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Justin Ryder, PhD · PRINCIPAL_INVESTIGATOR · Ann & Robert H Lurie Children's Hospital of Chicago
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in fat mass regain after initial weight loss with meal replacement therapy (MRT)17 weeks.
We hypothesize that the greater the initial weight loss with MRT the greater the fat mass regain at 26 weeks.
- Change in ghrelin17 weeks.
We hypothesize that after the initial weight loss with MRT that we will see an increase in the level of the appetite regulating hormone ghrelin.
- Change in gastric inhibitory polypeptide17 weeks
We hypothesize that after the initial weight loss with MRT that we will see an increase in the level of the appetite regulating hormone gastric inhibitory polypeptide.