SCORES for Psychosis Risk

This study is testing an intervention called SCORES (Specific COgnitive Remediation with Support) for young people aged 14 to 20 who are at high risk for psychosis (a mental health condition that affects how your brain processes information). SCORES is a 10-week program that combines cognitive remediation (brain training exercises) with group coaching and therapy. The goal is to improve processing speed (how quickly your brain can take in and use information), which may then help with social functioning and reduce early symptoms of psychosis. To join, you need to meet specific criteria for being at clinical high risk for psychosis and have certain scores on cognitive tests. The study will measure processing speed at the beginning, middle, and end of the 10-week program to see if SCORES is effective. The current status of this study is unclear, and it plans to enroll 54 participants.

Study design
This is an interventional study with a planned enrollment of 54 participants. It evaluates the SCORES intervention, which includes cognitive remediation and group support.
What's involved
Participants will complete 40 hours of cognitive remediation (4 hours per week for 10 weeks). There will be assessments at the beginning, at 5 weeks, and at 10 weeks.
Compensation
Not stated in the trial record.
Follow-up
Processing speed will be measured at baseline, mid-treatment (5 weeks), and post-treatment (10 weeks).

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NCT05131035

Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk

Recruiting
NAAges 14–20Interventional
Northwell Health
~54 participants
Updated 2025-11-24 on ClinicalTrials.gov
What's tested:SCORES (Specific COgnitive Remediation with Support)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Processing Speed domain score from the MATRICS Consensus Cognitive Battery (MCCB)
Measured over Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks)
Psychosis
Prodromal Schizophrenia
Prodromal Symptoms
1 sites across 1 states
New York1
  • Ricardo E Carrion, Ph.D. · PRINCIPAL_INVESTIGATOR · Northwell Health

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Meet Clinical High Risk (CHR) criteria on the Structured Interview for Psychosis Risk Syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level
A score representing 0.5 SD below the mean on Animal Naming, Trails A or BACS: Symbol Coding from the MATRICS Consensus Cognitive Battery (MCCB).

Exclusion

Any DSM 5 Schizophrenia-Spectrum diagnosis
Non-English speaking
Past or current history of a clinically significant central nervous system disorder (e.g., seizure disorder)
Estimated IQ\<70
Significant head injury
Significant substance abuse
Significant visual or auditory impairment.
  • Processing Speed domain score from the MATRICS Consensus Cognitive Battery (MCCB)Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks)

    Change in processing speed domain score and individual measures within the domain.