Post-operative Pain Control After C-section

This study is looking at ways to manage pain after a C-section (cesarean delivery). Researchers want to see if using an ON-Q Pump® that continuously delivers bupivacaine (a local anesthetic, or numbing medicine) helps reduce the amount of opioid pain medicine you need after surgery. You could be eligible if you are a pregnant patient, aged 18 to 50, and are having a C-section at Children's Hospital Colorado's Colorado Fetal Care Center. The study will compare pain control using bupivacaine to a pump delivering saline (salt water). The main goal is to measure how much opioid pain medicine participants use up to four days after surgery. The current status of this study is unclear.

Study design
This is an interventional study planning to enroll 100 women. Participants will be randomly assigned to receive either bupivacaine or saline through a pump.
What's involved
You would have an ON-Q Pump® connected to a catheter and left in place for up to 4 days after your C-section, or until the infusion is complete.
Compensation
Not stated in the trial record.
Follow-up
Your opioid use will be measured up to post-operative day 4.

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NCT05131178

Post-operative Cesarean Trial of Pain Control

Recruiting
NAAges 18–50InterventionalTreatment
University of Colorado, Denver
~100 participants
Updated 2026-02-06 on ClinicalTrials.gov
What's tested:ON-Q Pump® with continuous infusion of bupivacaineON-Q Pump® with continuous infusion of saline

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total postoperative opioid use
Measured over Post-operative day 4
Post-operative Pain
Cesarean Section
1 sites across 1 states
Colorado1
  • Michael Zaretsky, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Colorado - Colorado Fetal Care Center

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Eligibility criteria

Inclusion

Pregnant patients 18 years of age or older
Patients undergoing both scheduled and unscheduled cesarean deliveries at CFCC

Exclusion

Active substance abuse (ex methamphetamines) determined by patient report, toxin screen, or screening physician's determination
Current treatment for chronic pain involving opiate receptor agonism or antagonism (i.e. suboxone, methadone, naltrexone, oxycodone)
Contraindication to neuraxial anesthesia
Known allergies to common anesthetic medications
Inability to consent to study procedures
Patient receiving general anesthesia
  • Total postoperative opioid usePost-operative day 4

    Total postoperative opioid use in morphine equivalents through discharge