Prebiotics to Improve Gut Health After Stem Cell Transplant

This study is exploring whether a prebiotic called resistant starch (Bob's Red Mill® potato starch) can improve the diversity of your gut microbiome (the community of bacteria in your intestines) after an autologous cellular therapy (a type of stem cell transplant using your own cells). A healthier gut microbiome has been linked to better outcomes for people with multiple myeloma or lymphoma. You would receive either resistant starch or a placebo (maltodextrin) mixed into a food item daily for about 10 days before your stem cell infusion and continue until your white blood cell count recovers. The study aims to see if participants take at least 70% of their scheduled doses. This study is for adults aged 19 and older with multiple myeloma or certain types of lymphoma who are undergoing an autologous stem cell transplant. About 30 people are expected to join.

Study design
This is a randomized, double-blind study, meaning you would be randomly assigned to receive either resistant starch or a placebo, and neither you nor your doctors would know which you are receiving. It plans to enroll 30 participants.
What's involved
You would take a dietary supplement mixed into food daily for approximately 10 days before your stem cell infusion and continue until your white blood cell count recovers. Fecal samples will be collected at four different times.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is measured at 35 days, which suggests follow-up for at least this duration.

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NCT05135351

Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy

Recruiting
NAAges 19+InterventionalSupportive care
University of Nebraska
~30 participants
Updated 2026-07-27 on ClinicalTrials.gov
What's tested:Resistant StarchMaltodextrin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of subjects who adhere to >70% of scheduled doses of the intervention
Measured over 35 Days
Multiple Myeloma
Lymphoma
1 sites across 1 states
Nebraska1
  • Christopher R D'Angelo, MD · PRINCIPAL_INVESTIGATOR · University of Nebraska

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  • Percentage of subjects who adhere to >70% of scheduled doses of the intervention35 Days

    To understand the feasibility of the intervention in the proposed study population, the percentage of subjects who adhere to \>70% of scheduled doses will be calculated