Empagliflozin and Potassium Nitrate for Heart Failure with Preserved Ejection Fraction (HFpEF)
This study is looking at whether Empagliflozin, a medication that may improve how your body's cells use energy, with or without Potassium Nitrate, can help people with Heart Failure with Preserved Ejection Fraction (HFpEF). HFpEF is a condition where your heart can pump blood normally, but it's too stiff to fill properly. The study will see if these treatments improve how long you can exercise. You might be able to join if you are 18 or older, have HFpEF symptoms (NYHA Class II-III), and your heart's pumping ability (ejection fraction) is 50% or higher. The study plans to enroll 53 participants, but its current status is unclear.
- Study design
- This interventional study will compare Empagliflozin plus Potassium Nitrate, Empagliflozin plus Potassium Chloride, and Potassium Chloride plus a placebo for Empagliflozin. It aims to enroll 53 participants.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint, submaximal exercise endurance, is measured at Week 6.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Payman Zamani, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
Who to contact
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What this trial measures
- Submaximal Exercise EnduranceWeek 6
Time to exhaustion while exercising at 75% peak workload