Avera Cancer Sequencing and Analytics Protocol (ASAP)

This study, called ASAP, aims to understand the genetic makeup of cancers and pre-cancerous conditions in patients receiving care within the Avera healthcare system. Researchers will use comprehensive genomic profiling (looking at your genes) to identify the underlying genetic changes that drive these conditions. This involves testing tumor tissue and/or blood using next-generation sequencing (a way to read DNA). They will also perform pharmacogenomic testing to see how your genes might affect your response to medications, which could help optimize your treatment. You may be able to join if you are at least 18 years old and are being evaluated for a pre-cancerous condition or have a cancer diagnosis. The study hopes to enroll 25,000 participants and will measure how many patients receive comprehensive molecular profiling, are referred for genetic testing for their family members, and are referred for clinical trials targeting specific genetic changes, all over a 5-year period.

Study design
This is an observational study, meaning researchers will collect information without giving any specific interventions. It plans to enroll 25,000 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Researchers will track certain outcomes for 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05142033

Avera Cancer Sequencing and Analytics Protocol (ASAP)

Recruiting
Not specifiedAges 18+Observational
Avera McKennan Hospital & University Health Center
~25,000 participants
Updated 2026-03-27 on ClinicalTrials.gov

At a glance

Recruiting sites
6 of 6 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percent of patients participating in comprehensive molecular profiling
Measured over 5 years
+2 more outcomes measured
Cancer
Cancer Diagnosis
Early Detection of Cancer
Breast Cancer
Lung Cancer
Colon Cancer
GI Cancer
Gynecologic Cancer
Ovarian Cancer
Endometrial Cancer
CNS Cancer
Hematologic Cancer
6 sites across 2 states
South Dakota5
Minnesota1
  • Rachel Elsey, PharmD · PRINCIPAL_INVESTIGATOR · Avera Cancer Institute

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Eligibility criteria

Inclusion

Must be at least 18 years of age
Must be undergoing a workup or being followed for a premalignant condition or have a diagnosis of cancer
Must voluntarily sign and understand the most current IRB-approved consent form prior to study participation

Exclusion

Participants incapable of understanding the items listed in the consent form and process
Participants with a history of or known psychiatric illness deemed unable to consent or adhere to study requirements
  • Percent of patients participating in comprehensive molecular profiling5 years
  • Percent of patients referred for cascade genetic testing5 years
  • Percent of patients referred for molecularly targeted clinical trials5 years