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Remote Ischemic Preconditioning for Preventing Kidney Injury After Angiograms

This study is looking at whether a technique called Remote Ischemic Preconditioning (RIPC) can prevent kidney damage (Contrast-induced Acute Kidney Injury, or CI-AKI) in patients having a coronary angiogram. A coronary angiogram is a procedure where special dye (contrast medium) is used to see your heart's blood vessels. Sometimes, this dye can harm the kidneys. RIPC involves briefly cutting off blood flow to your arm using a blood pressure cuff, which might help protect your kidneys. The study will measure your kidney function (serum creatinine) before and after the angiogram to see if RIPC is effective. You may be able to join if you are having a coronary angiogram and meet certain kidney function criteria. The study aims to reduce the number of people who develop CI-AKI.

Study design
This is an interventional study with a planned enrollment of 300 participants. The study's status is currently unclear.
What's involved
You would have a blood pressure cuff placed on your non-dominant arm and inflated for 5 minutes. Your serum creatinine would be measured 48-72 hours after your coronary angiogram and again 6 weeks later.
Compensation
Not stated in the trial record.
Follow-up
Your kidney function will be checked 48-72 hours after the procedure and again 6 weeks later.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05147831

Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.

Recruiting
NAAges 18+InterventionalPrevention
The University of Texas Medical Branch, Galveston
~300 participants
Updated 2025-05-09 on ClinicalTrials.gov
What's tested:Remote Ischemic Preconditioning

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Serum Creatinine
Measured over Patient's serum creatinine would be measured 48-72 hours after coronary angiogram, and re-measured 6 weeks after coronary angiogram.

Conditions

Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI)
Contrast-induced Nephropathy Following Coronary Angiogram (CIN)

Explore related trials

Acute kidney injury caused by contrast agentCoronary Artery Disease

Where it's being run

1 sites across 1 states
Texas1

Who to contact

Salman Salehin, MD
[email protected]
+12818189321
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

(1) Patients undergoing an interventional or diagnostic radiological procedure in which they receive intravascular contrast, including patients undergoing coronary angiogram +/- percutaneous coronary intervention (PCI) for all clinical indications except those indicated for primary PCI due to STEMI
(2) patients presenting with a renal clearance in the range of less than 60 ml/min/1.73 m2 but not declared ESRD
(3) Patients who are not yet recruited for other pharmacological or medical device clinical trials.

Exclusion

(1) Age \<18 years
(2) Patient on hemodialysis or peritoneal dialysis
(3) Simultaneous participation in another interventional study
(4) Percutaneous coiling/embolization procedures of the kidney
(5) Impossibility to perform RIPC, caused by pathology in both arms (e.g. dystrophy, recent trauma, chronic wounds)
(6) No written informed consent
(7) Urgent angiography in STEMI
(8) Cardiogenic shock requiring catecholamine infusion
(9) Systolic blood pressure \<80 mmHg
(10) Intra-aortic balloon counter-pulsation
(11) Contrast medium injection within the previous 30 days
(12) Expected impossibility to obtain follow-up data at 6-week follow-up
(13) Patients with Raynaud's disease

What this trial measures

  • Serum CreatininePatient's serum creatinine would be measured 48-72 hours after coronary angiogram, and re-measured 6 weeks after coronary angiogram.

    The primary outcome would be the incidence of CI-AKI, which is defined as an increment of serum creatinine ≥ 0.5 mg/dL or a relative increase of ≥ 25% over the baseline value within a period of 48-72 hours after contrast medium administration.