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Cataract Surgery Dropless Regimen Study

This study is looking at a new way to care for patients after cataract surgery at Zuckerberg San Francisco General Hospital. Many patients find it hard to use the multiple eye drops currently prescribed after surgery, which can lead to problems. This study compares the standard regimen of eye drops (Neomycin/Polymyxin B and Ketorolac 0.5%) with a "dropless" approach. The dropless approach involves injections of triamcinolone acetonide and cefuroxime given during surgery, so you wouldn't need to use drops afterward. The researchers want to see if the dropless method improves how well patients follow their treatment plan and how satisfied they are. You may be able to join if you are 18 or older, a ZSFG patient needing cataract surgery in both eyes, and plan to have both eyes treated. The study aims to enroll 70 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 70 participants. It compares two different treatment approaches for cataract surgery aftercare.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your compliance with the regimen and satisfaction will be measured at one week and one month after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05157113

Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

Recruiting
PHASE4Ages 18+InterventionalPrevention
University of California, San Francisco
~70 participants
Updated 2025-07-23 on ClinicalTrials.gov
What's tested:Dropless RegimenStandard Regimen

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient Compliance with Postoperative Regimen
Measured over Post Operative Week 1
+3 more outcomes measured

Conditions

Cataract
Surgery
Compliance, Patient
Compliance, Medication
Satisfaction, Patient

Explore related trials

Cataract

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Sriranjani P Padmanabhan, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

Sriranjani Padmanabhan, MD
[email protected]
415-514-0241
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

ZSFG patient initially seen in the eye clinic, approved by attending ophthalmologist for cataract surgery in both eyes due to visually significant cataracts, and who elects to have cataract surgery in both eyes.
Patients 18 years of age or older

Exclusion

Patients requiring bilateral simultaneous (same-day bilateral) cataract surgery
Patients with prior history of: endophthalmitis, advanced glaucoma, known history of intraocular pressure elevation due to steroids, prior intraocular surgery, cystoid macular edema/diabetic macular edema/retinal edema noted in the past 12 months prior to cataract surgery
Patients with documented penicillin or cephalosporin allergy or intolerance
Patients requiring combined same day cataract and ophthalmic subspecialty procedure (eg; combined cataract and glaucoma, retina, or cornea surgery).
Patients who are pregnant or breastfeeding

What this trial measures

  • Patient Compliance with Postoperative RegimenPost Operative Week 1

    Compliance will be reported via a language-specific VOILS DOSE Nonadherence Survey and an in-person verbal/visual adherence check with staff. The survey is separated into two parts: Extent of Nonadherence and Reasons for Nonadherence. Extent of Nonadherence will evaluate whether medicine dosages have been skipped or missed, with a variety of options ranging from "none of the time" to "every time." Reasons for Nonadherence will present possible causes of missed/skipped dosage, with a variety of options ranging from "not at all" to "very much."

  • Patient Compliance with Postoperative RegimenPost Operative Month 1

    Compliance will be reported via a language-specific VOILS DOSE Nonadherence Survey and an in-person verbal/visual adherence check with staff. The survey is separated into two parts: Extent of Nonadherence and Reasons for Nonadherence. Extent of Nonadherence will evaluate whether medicine dosages have been skipped or missed, with a variety of options ranging from "none of the time" to "every time." Reasons for Nonadherence will present possible causes of missed/skipped dosage, with a variety of options ranging from "not at all" to "very much."

  • Patient SatisfactionPost Operative Month 1

    Patients will rate their post-operative recovery on a Likert Scale of 1-5, with 1 being "very unsatisfied" and 5 being "very satisfied." Supplemental questions are included to obtain the patients' opinions on their eyesight, pain, and personal experience with the post-operative routine. After undergoing a second eye surgery and post-operative treatment, the survey will be given again with an additional question asking patients to indicate their preference between the two post-operative regimens as a binary choice.

  • Caregiver SatisfactionPost Operative Month 1

    Caregivers will also rate their satisfaction with the patients' post-operative recovery on a Likert Scale of 1-5, with 1 being "very unsatisfied" and 5 being "very satisfied." Supplemental questions are included to obtain the caregivers' personal experience with the post-operative routine. After the patient's second eye surgery and post-operative treatment, the survey will be given again with an additional question asking caregivers to choose between the two post-operative regimens as a binary choice.