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MAVERIC Registry: Myocarditis and Premature Ventricular Contractions

This observational study, called the MAVERIC Registry, is looking into a possible connection between unrecognized heart inflammation (myocarditis) and irregular heartbeats called premature ventricular contractions (PVCs). Researchers believe that hidden inflammation might be a reason why some people experience PVCs, even with or without a weakened heart (reduced left ventricular ejection fraction or LVEF). The study aims to identify myocarditis in patients who have PVCs. You might be able to join if you are over 18 and have at least 5,000 PVCs in a 24-hour period, or if you have non-sustained ventricular tachycardia (VT). You cannot join if you have a history of heart attack or significant coronary artery disease. The study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning researchers are looking at existing patient information. It plans to include 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is to identify myocarditis using information collected retrospectively between January 2014 and January 2023.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05158751

Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry

Not Yet Recruiting
Not specifiedAges 18+Observational
Kansas City Heart Rhythm Research Foundation
~100 participants
Updated 2025-09-04 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF
Measured over Retrospective Collection between dates January 2014-January 2023

Conditions

Myocarditis
Premature Ventricular Contractions
Ventricular Tachycardia (VT)

Explore related trials

MyocarditisVentricular premature complexVentricular Tachycardia

Where it's being run

1 sites across 1 states
Kansas1

Study leadership

  • Dhanunjaya Lakkireddy, MD · PRINCIPAL_INVESTIGATOR · Kansas City Heart Rhythm Institute

Who to contact

Donita Atkins
[email protected]
816-651-1969
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients \> 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
Non-sustained VT was defined as ≥3 more consecutive beats lasting \<30 seconds

Exclusion

History of myocardial infarction,
Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
History of revascularization,
Significant symptomatic atrial arrhythmias associated with LV dysfunction,
Severe valvular disease,
Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
History of cardiac arrest,
History of channelopathies or inherited arrhythmias.

What this trial measures

  • Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEFRetrospective Collection between dates January 2014-January 2023

    To identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF through laboratory testing, FDG-PET(18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose - positron emission tomography) scan, Cardiac Magnetic Resonance imaging and/or Endomyocardial biopsy.