Study of Transdermal Human Insulin for Type 2 Diabetes

This study is testing a new way to deliver human insulin for people with Type 2 Diabetes. Instead of injections, insulin is delivered through the skin using a finger-actuated pump sprayer. Researchers want to see how well this transdermal (through the skin) human insulin works to control blood sugar compared to traditional injected insulin. The study will measure the percentage of time participants' blood sugar stays within a healthy range over 21 days. They are looking for 30 adults, aged 25 to 75, who currently manage their Type 2 Diabetes with insulin injections and have well-controlled blood sugar levels.

Study design
This is an open-label study, meaning both participants and researchers will know which treatment is being given. It will involve 30 participants with Type 2 Diabetes.
What's involved
You would be monitored with a Continuous Glucose Monitor (CGM) for two weeks before starting the transdermal insulin. During the 21-day study, you'll use the transdermal insulin and continue CGM monitoring, calibrating it with finger-stick tests every 8 hours. You will also be monitored for 7 days after your last transdermal dose.
Compensation
Not stated in the trial record.
Follow-up
Participants will be monitored for 7 days after the last transdermal dose.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05159453

Dose Response Study of Transdermal Human Insulin in Patients

Not Yet Recruiting
PHASE2Ages 25–75InterventionalTreatment
Transdermal Delivery Solutions Corp
~30 participants
Updated 2026-05-26 on ClinicalTrials.gov
What's tested:Human InsulinFinger-actuated, Metered Pump Sprayer

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of Glucose Time in Range for Study Participants
Measured over 21 Days
Glucose, High Blood
1 sites across 1 states
Florida1
  • Chandan A.S. Alam, MD · PRINCIPAL_INVESTIGATOR · Langford Research Institute

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  • Percentage of Glucose Time in Range for Study Participants21 Days

    Number of Participants who manage blood glucose in study participants to between 70 and 200 mg Glucose / dL.