Vaccine Responses in Patients With B Cell Malignancies

This study is looking at how well vaccines work in people with certain blood cancers, specifically chronic lymphocytic leukemia (CLL), Waldenstrom macroglobulinemia, and some non-Hodgkin lymphomas. Researchers want to see how your body responds to vaccines like AREXVY, ABRYSVO (for RSV), PREVNAR 20, PNEUMOVAX 23, PREVNAR 13 (for pneumonia), and Heplisav-B (for Hepatitis B). People with these cancers often have a weaker immune response, and some cancer treatments like Bruton tyrosine kinase inhibitors (BTKis) might also affect vaccine effectiveness. The main goal is to measure your immune response (serologic response) to each vaccine about four weeks after you've completed the vaccine series. This study is currently unclear about its recruitment status and plans to enroll about 350 participants aged 18 to 90.

Study design
This interventional study plans to enroll about 350 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your immune response will be measured at 4 weeks after completing the vaccine series.

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NCT05170399

Vaccine Responses in Patients With B Cell Malignancies

Recruiting
PHASE4Ages 18–90InterventionalBasic science
National Heart, Lung, and Blood Institute (NHLBI)
~350 participants
Updated 2026-08-04 on ClinicalTrials.gov
What's tested:AREXVY, ABRYSVOPREVNAR 20PNEUMOVAX 23Heplisav -BPREVNAR 13Shingrix

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Serologic response against each administered vaccine following completion of the vaccine series in each study arm
Measured over 4 weeks after completing vaccine series
Lymphoma
1 sites across 1 states
Maryland1
  • Adrian U Wiestner, M.D. · PRINCIPAL_INVESTIGATOR · National Heart, Lung, and Blood Institute (NHLBI)

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Eligibility criteria

Inclusion

Diagnosis of CLL, FL, MCL, MZL, NHL NOS or WM
Must fulfil one of the following criteria to be enrolled in one study arm per vaccine received:
If prior exposure to Hepatitis-B vaccination, must have documentation of negative serologic response
Age \>= 18 years
Able to comprehend the investigational nature of the protocol and provide informed consent
  • Serologic response against each administered vaccine following completion of the vaccine series in each study arm4 weeks after completing vaccine series

    vaccine titer