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Full-Field Optical Coherence Tomography for Lung Biopsies

This study is looking at a new imaging technique called Full-Field Optical Coherence Tomography (FFOCT) to examine small lung tissue samples. These samples are collected during a procedure called bronchoscopy, which is used to diagnose conditions like lung cancer and sarcoidosis. FFOCT creates detailed images of the tissue, similar to standard lab tests, but it's faster and helps preserve the sample for other tests. Researchers want to see how well FFOCT results match the results from standard lab tests. You might be able to join if you are 18 or older, are having a bronchoscopy for diagnosis, and can give informed consent. The study aims to enroll 20 participants, but its current status is unclear.

Study design
This is an observational study involving about 20 participants. It is not a randomized or blinded study.
What's involved
You would be undergoing a bronchoscopy as part of your standard medical care, and the study would use the small tissue samples collected during that procedure.
Compensation
Not stated in the trial record.
Follow-up
The primary goal is measured at 1 year, which suggests a follow-up period for comparing results.

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NCT05171478

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Recruiting
Not specifiedAges 18+Observational
Johns Hopkins University
~20 participants
Updated 2025-12-17 on ClinicalTrials.gov
What's tested:Full-field optical coherence tomography

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Correlation of FFOCT to standard histology as assessed by the kappa value
Measured over 1 year

Conditions

Lung Cancer
Sarcoidosis

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Lung CarcinomaSarcoidosis

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Jeffrey Thiboutot, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Jeffrey Thiboutot, MD
[email protected]
410-502-2533
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Inpatients or outpatients greater than or equal to 18 years old
Capable of providing informed consent
Undergoing bronchoscopy for diagnosis or staging per standard of care
Collection of small biopsy samples by EBUS or conventional transbronchial needle aspiration (TBNA) or transbronchial biopsy for purposes outside of the research study

Exclusion

Standard contraindications bronchoscopy including bleeding disorders, antiplatelet or anticoagulant usage, severe respiratory failure, and clinical instability
Pregnancy

What this trial measures

  • Correlation of FFOCT to standard histology as assessed by the kappa value1 year

    Correlation of FFOCT to standard histology will be assessed by the kappa value of correlation.