Dapagliflozin for Atrial Fibrillation in Patients with Diabetes
This study is looking at how a medication called Dapagliflozin might affect atrial fibrillation (AF), a type of irregular heartbeat, in people who also have diabetes. Researchers want to see if Dapagliflozin can reduce the amount of time you spend in AF. You would take either Dapagliflozin 10mg or a placebo (an inactive pill) once a day. This study is for adults aged 18 to 85 who have been diagnosed with diabetes and paroxysmal AF (AF that stops on its own or with help within seven days). You cannot join if you have Type 1 diabetes, very low blood pressure, severe kidney problems, or are taking certain other medications. The study aims to enroll 28 participants.
- Study design
- This is an interventional study where participants will be randomly assigned to receive either Dapagliflozin or a placebo. The study is blinded, meaning neither you nor your doctor will know which treatment you are receiving.
- What's involved
- You would take one blinded tablet daily. Your heart rhythm will be monitored continuously for two weeks at the beginning and again at three months.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary endpoint for measuring the effect of Dapagliflozin is at 3 months.
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Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Zain Ul Abideen Asad, MD · PRINCIPAL_INVESTIGATOR · University of Oklahoma
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- The effect of Dapagliflozin on change in burden of atrial fibrillationBaseline and 3 months
To determine the effect of Dapagliflozin on change in AF burden in patients with AF and DM. AF burden will be defined as the percent of time spent in AF over a 2-week period, assessed by noninvasive continuous heart rhythm monitoring at baseline and at 3 months. The AF burden between Dapagliflozin vs Placebo will be compared.