Dapagliflozin for Atrial Fibrillation in Patients with Diabetes

This study is looking at how a medication called Dapagliflozin might affect atrial fibrillation (AF), a type of irregular heartbeat, in people who also have diabetes. Researchers want to see if Dapagliflozin can reduce the amount of time you spend in AF. You would take either Dapagliflozin 10mg or a placebo (an inactive pill) once a day. This study is for adults aged 18 to 85 who have been diagnosed with diabetes and paroxysmal AF (AF that stops on its own or with help within seven days). You cannot join if you have Type 1 diabetes, very low blood pressure, severe kidney problems, or are taking certain other medications. The study aims to enroll 28 participants.

Study design
This is an interventional study where participants will be randomly assigned to receive either Dapagliflozin or a placebo. The study is blinded, meaning neither you nor your doctor will know which treatment you are receiving.
What's involved
You would take one blinded tablet daily. Your heart rhythm will be monitored continuously for two weeks at the beginning and again at three months.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint for measuring the effect of Dapagliflozin is at 3 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05174052

Dapagliflozin in Patients With Atrial Fibrillation (DAPA-AF)

Recruiting
PHASE3Ages 18–85InterventionalTreatment
University of Oklahoma
~28 participants
Updated 2026-04-01 on ClinicalTrials.gov
What's tested:Dapagliflozin 10Mg TabPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The effect of Dapagliflozin on change in burden of atrial fibrillation
Measured over Baseline and 3 months
Diabetes Mellitus
Atrial Fibrillation
1 sites across 1 states
Oklahoma1
  • Zain Ul Abideen Asad, MD · PRINCIPAL_INVESTIGATOR · University of Oklahoma

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Diagnosed with DM
Paroxysmal AF

Exclusion

Type 1 DM,
Symptoms of hypotension or systolic blood pressure \<90mmHg,
Severe renal impairment with eGFR\<30mL/minute/1.73m2,
History of lower limb amputation,
Hypersensitivity to Dapagliflozin,
Currently taking any SGLT2i,
Pregnancy,
Currently taking anti-arrhythmic drugs
Undergoing catheter ablation will be excluded
  • The effect of Dapagliflozin on change in burden of atrial fibrillationBaseline and 3 months

    To determine the effect of Dapagliflozin on change in AF burden in patients with AF and DM. AF burden will be defined as the percent of time spent in AF over a 2-week period, assessed by noninvasive continuous heart rhythm monitoring at baseline and at 3 months. The AF burden between Dapagliflozin vs Placebo will be compared.