Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction

This study is looking at what happens when people with a type of heart failure called Heart Failure With Preserved Ejection Fraction (HFpEF) stop taking their beta-blocker medication. Researchers want to see if stopping beta-blockers changes how you feel and your quality of life. They will measure this using a questionnaire called the KCCQ-23 score. You might be able to join if you are between 50 and 80 years old, have stable HFpEF, and are currently taking a beta-blocker. The study aims to enroll 30 participants, but its current recruitment status is unclear.

Study design
This is a pilot study that will look at changes in 30 participants before and after stopping beta-blockers. It is an interventional study, meaning participants will receive a specific intervention.
What's involved
You would have two study visits over a period of about 4 weeks. The first visit is a standard clinic visit, and the second involves questionnaires and a limited echocardiogram (a heart ultrasound).
Compensation
Not stated in the trial record.
Follow-up
There is no long-term follow-up beyond the second visit, which occurs 4 weeks after stopping beta-blockers.

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NCT05174351

Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction

Recruiting
NAAges 50–80InterventionalTreatment
UConn Health
~30 participants
Updated 2025-09-29 on ClinicalTrials.gov
What's tested:beta blocker discontinuation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Changes in KCCQ-23 score
Measured over Baseline and after 4 weeks of beta blocker discontinuation
Heart Failure With Preserved Ejection Fraction
1 sites across 1 states
Connecticut1
  • Kai Chen, MD,PhD · PRINCIPAL_INVESTIGATOR · UConn Health

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Eligibility criteria

Inclusion

Stable HFpEF patients with NYHA Class II-III or elevated BNP ≥100
N=30 (Target: 30).
Age: 50 \~ 80 years.
ECHO evidence of EF ≥50% and Grade 2 or 3 diastolic dysfunction.
Chronic loop diuretic use
Currently on beta-blocker

Exclusion

Beta blocker was prescribed for treating other cardiac conditions such as atrial fibrillation or coronary artery disease.
Heart rate \> 100 bpm
Recent hospitalization due to HF within 3 months
Non-English speaker
  • Changes in KCCQ-23 scoreBaseline and after 4 weeks of beta blocker discontinuation

    Kansa city cardiomyopathy questionnaire (KCCQ-23)- self-administered, 23-item. questionnaire that quantifies physical limitations, symptoms, self-efficacy, social interference and quality of life. Scores are transformed to a range of 0-100, where higher scores reflect better health status.