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Esophageal and Gastric Registry and Biorepository

This observational study is collecting information about the esophagus and stomach in healthy individuals. You would undergo esophageal studies, which involve tests of your esophagus and blood. The researchers are looking to establish normal values for mucosal integrity (the health of the lining of your esophagus) and pyloric FLIP (a test that measures how your stomach outlet opens and closes) over one year. To join, you should be between 18 and 85 years old, have no prior surgeries, be asymptomatic (have no symptoms) related to your stomach or esophagus, and not be taking medications that affect acid or gut movement. You also shouldn't have a history of cancer, mental health issues that prevent informed consent, smoking, excessive alcohol use, a BMI over 30, or a known hiatal hernia. The current recruitment status is unclear.

Study design
This is an observational study with a planned enrollment of 40 healthy participants.
What's involved
You would undergo esophageal and blood testing, with primary measurements taken at one year.
Compensation
Not stated in the trial record.
Follow-up
Primary measurements for mucosal integrity and pyloric FLIP values will be taken at 1 year.

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NCT05180253

Esophageal and Gastric Registry and Biorepository

Recruiting
Not specifiedAges 18–85Observational
University of Louisville
~40 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:Esophageal studies

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Normative mucosal integrity values
Measured over 1 year
+1 more outcome measured

Conditions

Gastro Esophageal Reflux

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Gastroesophageal Reflux Disease

Where it's being run

1 sites across 1 states
Kentucky1

Who to contact

Benjamin Rogers
[email protected]
502-852-6991
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Eligibility criteria

Inclusion

Age 18-85
No prior surgical history
Asymptomatic according to gastroesophageal and gastric questionnaires
Not currently taking any medications that affect acid secretion or gut motility
No history of malignancy
No mental health issues precluding informed consent
No smoking history
No excessive or daily alcohol use
BMI \< 30
No known hiatus hernia
No known medical illness (autoimmune, neurological) that could be associated with altered esophageal or gastric function
Not allergic to fentanyl or versed
No history of eating disorder
No history of autoimmune disorders

Exclusion

Minors
Surgeries involving the GI tract
Medication use affecting acid secretion or gut motility
Personal history of malignancy
Mental health issues precluding informed consent
Symptoms on standard clinical questionnaires
Pregnant - the effect that pregnancy has on esophageal and gastric motility is not well defined, but we will need to eliminate this as a confounding factor
Nursing women - although the investigations are FDA approved and part of standard clinic practices, they are time consuming and involve medication administration that might affect the ability of a mother to nurse

What this trial measures

  • Normative mucosal integrity values1 year

    We will establish the range of MI values in healthy, asymptomatic individuals.

  • Normative pyloric FLIP values1 year

    We will further establish the range of FLIP values that can be seen in healthy, asymptomatic individuals.