Study for Alcohol and Nicotine Use Disorder

This study is for adults who want to reduce their alcohol use and stop smoking. It's testing a behavioral treatment called Contingency Management (CM), which offers incentives for submitting urine samples that show no alcohol. Some participants will receive incentives for simply submitting samples, regardless of the result. This treatment is combined with varenicline (a medication for smoking cessation) and counseling videos. The study aims to see how well CM can help people decrease their alcohol and tobacco use over a 12-week treatment period and then for 7 months afterward. To join, you must be 18 or older, seeking treatment for both alcohol use disorder (AUD) and smoking, and meet specific criteria for alcohol consumption. The current recruitment status is unclear.

Study design
This is a randomized controlled trial, meaning participants are assigned by chance to different treatment groups. The study plans to enroll 205 participants.
What's involved
Participants will submit urine samples. The study involves a 12-week treatment period and a 7-month follow-up period.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 7 months after the 12-week treatment period.

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NCT05181891

Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking

Recruiting
PHASE2Ages 18+InterventionalTreatment
Washington State University
~205 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:Contingency ManagementNon-contingent control

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Biochemically Verified Alcohol Use
Measured over 12-week treatment period and 7-month follow-up period
+1 more outcome measured
Alcohol Use Disorder (AUD)
Nicotine Use Disorder
1 sites across 1 states
Washington1
  • Sterling M McPherson, PhD · PRINCIPAL_INVESTIGATOR · Washington State University

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  • Change in Biochemically Verified Alcohol Use12-week treatment period and 7-month follow-up period

    Consumption of alcohol between participants randomized to CM+TAU vs NC+TAU assessed by alcohol EtG values (collected 3x weekly from weeks 1-14, and once at weeks 18, 30, 42).

  • Change in Biochemically Verified Tobacco Use12-week treatment period and 7-month follow-up period

    Consumption of tobacco between participants randomized to CM+TAU vs NC+TAU assessed by tobacco CO and COT values (collected 3x weekly from weeks 1-14, and once at weeks 18, 30, 42).