NCT05193149
Inspiratory Muscle Training in Obese Breast Cancer Survivors
Completed
NAAges 18+InterventionalSupportive careOhio State University Comprehensive Cancer CenterInvestigator-initiated
~77 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:Inspiratory muscle trainingExercise training
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in exercise tolerance
Measured over Baseline to 4 weeks
+1 more outcome measured
Conditions
Where it's being run
1 sites across 1 statesOhio1
Study leadership
- Dharini M Bhammar, PhD · PRINCIPAL_INVESTIGATOR · Ohio State University
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Inclusion
completed active treatment for a Stage 0-III breast cancer diagnosis within 6 months to 5 years of enrollment.
obese as defined by a body mass index (BMI) of 30 to 50 kg/m2
patients who are on adjuvant endocrine therapy will be allowed to participate.
sedentary (participating in less than 90 min of moderate intensity activity per week) and have at least one limitation in activity on the 10-question RAND-36 Physical Function Subscale to ensure some exercise intolerance
Exclusion
functional limitations that make independent exercise unsafe
metastatic breast cancer
ongoing or active infection with recent antibiotics or steroids
Bilateral Axillary lymph node dissection (ALND) of \>5 lymph nodes on each side, which could increase risk of lymphadenopathy with repeated blood pressure measurements during exercise or if patient has been advised by their clinician to avoid repeated BP measures on both arms. Bilateral Sentinel Lymph Node Biopsy (SLNB) will be allowed.
heart disease precluding exercise (congestive heart failure, unstable angina pectoris, cardiac arrhythmia)
psychiatric illness/social situations that would limit compliance with study requirements
orthopedic or neuromuscular disorders or arthritis that preclude participation in exercise
unwilling or unable to follow protocol requirements
pregnant or nursing
any condition which in the investigator's opinion deems the subject an unsuitable candidate to participate in this study
presence of provokable ECG changes suggestive of heart disease, or dangerous arrhythmias or exercise induced hypertension, etc. during the cardiopulmonary exercise test
non-English speaking
What this trial measures
- Change in exercise toleranceBaseline to 4 weeks
Continuous variable assessed as time to exhaustion during a CWRET at 80% of peak work rate. Units: minutes.
- Change in exercise toleranceBaseline to 16 weeks
Continuous variable assessed as time to exhaustion during a CWRET at 80% of peak work rate. Units: minutes.