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Observational Study for Early Cancer Detection

This is an observational study looking at healthy adults to better understand how cancer develops over a long period. Researchers are not testing any specific medicine or intervention. You can join if you are 18 or older and are having an upper or lower endoscopy (a procedure to look inside your digestive tract) for routine medical care. You cannot join if you currently have cancer or have been treated for most cancers within the last five years. The main goal is to see who develops cancer over a period of up to 20 years, and to connect this to lifestyle and clinical factors. This will help doctors find cancer earlier when it's easier to treat.

Study design
This is an observational study planning to enroll 10,000 healthy adults. It is designed to follow participants over a long period to see if they develop cancer.
What's involved
You will be followed for up to 20 years. The study will collect information on your lifestyle, medications, physical activity, and blood samples.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 20 years to track the development of malignancy.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05193305

Study of Healthy Cohort for Early Detection of Cancer

Recruiting
Not specifiedAges 18+Observational
Johns Hopkins University
~10,000 participants
Updated 2026-02-25 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Development of malignancy
Measured over Up to 20 years

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Elham Afghani · PRINCIPAL_INVESTIGATOR · Johns Hopkins University

Who to contact

Elham Afghani
[email protected]
410-955-5000
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

All adults 18 years of age of older undergoing upper or lower endoscopy for routine medical care.

Exclusion

Persons with current malignancy
Persons with history of malignancy and treatment within last 5 years of enrollment, excluding non-melanoma skin cancer or cervical in-situ.
Persons who are unable or unwilling to provide repeat blood samples and complete follow-up questionnaires
Persons who lack the capacity to provide consent
Persons who do not speak English
Persons who are visually or hearing impaired.

What this trial measures

  • Development of malignancyUp to 20 years

    Assessment of participants for the development of malignancy during a 20-year follow-up period.