Hot Flashes and Neurovascular Function in Women
This study is looking into the connection between hot flashes and heart health in women. Researchers want to understand how hot flashes might increase the risk of high blood pressure and other heart problems. They will compare women who have frequent hot flashes with those who have fewer. You would undergo tests involving different substances like Sodium Nitroprusside, Acetylcholine, Terbutaline, and Norepinephrine, which are infused through a catheter in your arm to see how your blood vessels respond. You would also perform activities like handgrip exercises and a cold pressor test to measure nerve activity. The study aims to see if there are differences in how blood vessels and nerves function in women with varying hot flash frequencies. The study is currently unclear on its recruitment status and plans to enroll 120 women between 40 and 60 years old who are non-smokers, not obese, have at least one ovary, and no cardiovascular disease or related medications.
- Study design
- This is an interventional study with a planned enrollment of 120 women. The phase of the study is not specified.
- What's involved
- You would have continuous measurements of vascular conductance during drug infusions (about 60 minutes total) and continuous measurement of muscle sympathetic nerve activity at rest and during stressors (about 75 minutes total).
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
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Hot Flashes and Neurovascular Function in Women
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Sarah Baker, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- Compare microvascular function in women with low and high frequency hot flashesContinuous measurement of vascular conductance during infusion of each drug- 3min at baseline and at each drug dose (~60min total of continuous forearm vascular conductance measurements)
Change in forearm vascular conductance with intra-arterial drug infusions. Vascular conductance is an index of vascular tone and is assessed using a technique called venous occlusion plethysmography
- Compare sympathetic function in women with low and high frequency hot flashesContinuous measurement of muscle sympathetic nerve activity at rest and in response to stressors (~75min of continuous data collection once a sympathetic nerve signal is found)
Muscle Sympathetic Nerve Activity will be directly using a technique called microneurography.