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Neurostimulation for Post-Stroke Aphasia

This study is exploring a new way to help people with aphasia (difficulty speaking or understanding language) after a stroke. It's testing if a type of brain stimulation called tACS (transcranial alternating current stimulation) at 75Hz, when combined with language exercises, can improve communication skills. You might be able to join if you are between 18 and 80 years old, have aphasia from a stroke (Broca's or mixed type), and score between 10% and 60% on a naming task. The researchers will measure success by looking at your score on a naming task after 12 weeks. The current status of this study is unclear.

Study design
This interventional study plans to enroll 64 participants. It is testing a device called Neuro Device tCS.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed up to 12 weeks after the intervention to measure your naming task scores.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05194566

Neurostimulation for the Treatment of Post-Stroke Aphasia

Recruiting
NAAges 18–80InterventionalTreatment
QVITI S.A.
~64 participants
Updated 2026-02-18 on ClinicalTrials.gov
What's tested:tACS

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage score in the Naming Task (trained words)
Measured over 12-week follow-up

Conditions

Post-stroke Aphasia

Explore related trials

Aphasia

NCT05194566

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Abilities Research Center at Mount Sinai

    New York, New Yorkstudy coordinator listed

    Recruiting

  • Think & Speak Lab at Shirley Ryan AbilityLab

    Chicago, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Miguel Escalon, MD, MPH · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

Who to contact

Tertia Jeppson
[email protected]
312-238-6163
Email the study team

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Eligibility criteria

Inclusion

diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist).
presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT/MRI examination);
chronic stage of the disease - time since the stroke occurred over 6 months.
ability to achieve an accuracy in the Naming Task of 10-60%.
18-80 years
right-handedness before the stroke.
ability to give informed written consent.
fluency in English.

Exclusion

severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command.
presence of metal implants in the skull.
presence of major untreated or unstable psychiatric disease.
history of epilepsy or seizures.
ongoing medication that increases the risk of epileptic seizures.
presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted).
history of speech, language, hearing, or intellectual disability during childhood.
pregnancy (based on declarations)
high intolerance to stimulation.
occurrence of an epileptic seizure.
other previously absent neurological or mental symptoms
high intolerance to stimulation (participants experience severe discomfort during stimulation);
occurrence of an epileptic seizure;
other previously absent neurological, physical or mental symptoms.

What this trial measures

  • Percentage score in the Naming Task (trained words)12-week follow-up

    The Baseline Naming Task consists of 344 images representing nouns and the images will be presented on the computer screen. The task is to name the presented noun by producing the name of the item out loud. The answer is scored on a three-point scale (1 - not able to name correctly, 2 - named with phonological or semantic paraphasia, 3 - correct). Items marked with a score of 3 are considered accurate. From the baseline assessment, a random list of 50 incorrectly named words will be trained in therapy. Minimum score is 0% (inability to name any objects) and maximum score is 100% (accuracy in naming all presented objects), where a higher score indicates a better health outcome