TDCS for Post-Stroke Cognitive Impairment
This study is looking at whether a treatment called anodal transcranial Direct Current Stimulation (A-tDCS) can help improve thinking and memory problems after a stroke. A-tDCS uses a device to deliver a mild electrical current to the brain. Participants will also receive computerized cognitive treatment (CCT). We are looking for about 60 adults, aged 18 to 100, who have recently had a minor stroke and are experiencing mild cognitive impairment. The study will measure changes in your thinking abilities and brain activity over 6 months to see if the treatment is successful. The current status of this study is unclear.
- Study design
- This is a randomized, double-blinded, sham-controlled study with about 60 participants. Participants will be randomly assigned to receive either A-tDCS or a sham (inactive) treatment, both combined with CCT.
- What's involved
- Participants will undergo 5 weeks of either A-tDCS + CCT or sham + CCT. Clinical evaluations and cognitive assessments will be performed at 1, 3, and 6 months after your stroke.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your cognition and brain activity will be measured at 1, 3, and 6 months after your stroke.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
TDCS to Improve Post-Stroke Cognitive Impairment
At a glance
Conditions
NCT05195398
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Johns Hopkins Bayview Medical Center
Baltimore, Marylandstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Elisabeth B Marsh, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Change in Cognition as assessed by our Cognitive BatteryAdministered at 1, 3, and 6 month post-stroke visits
Our cognitive battery was designed to efficiently evaluate for psMCI. It combines the Montreal Cognitive Assessment, Grooved Pegboard, Hopkins Verbal Learning Test, Brief Visuospatial Memory Test, Delis-Kaplan Executive Function System, and Symbol Digit Modalities Test. T scores are averaged across tasks and calculated for the following cognitive domains: verbal memory, spatial memory, processing speed, motor speed, executive function, and global cognition.
- Change in Functional Connectivity as assessed by MEGAdministered at 1, 3, and 6 month post-stroke visits
Participants will undergo an MEG evaluating global functional connectivity: 1) during resting state, and 2) during completion of a visual task. Connectivity will also be evaluated within the following specific cognitive networks: frontoparietal (executive) and limbic (memory)