Understanding Chronic Pain in Cerebral Palsy through MRI

This study is looking at how chronic pain (long-lasting pain) in people with cerebral palsy (CP), a group of disorders that affect a person's ability to move and maintain balance and posture, is connected to changes in the brain. Researchers will use special MRI (Magnetic Resonance Imaging) scans, which are detailed pictures of the inside of your body, to look at brain structure and function. They also want to understand how these brain changes relate to sensory issues. The goal is to find new ways to identify and understand different types of pain in people with CP, which could lead to better ways to manage it. This study is observational, meaning researchers will collect information without giving any new treatments, and plans to include 300 participants.

Study design
This is an observational study that aims to enroll 300 participants. It is not a treatment study, but rather focuses on understanding the links between brain changes and chronic pain in cerebral palsy.
What's involved
Participants will complete online questionnaires about pain symptoms and medical history. Some participants will also have a research MRI scan that lasts no more than 1.5 hours.
Compensation
Not stated in the trial record.
Follow-up
Brain and spine measurements will be taken at less than 3 months.

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NCT05197946

Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

Recruiting
Not specifiedAges 8+Observational
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
~300 participants
Updated 2026-06-29 on ClinicalTrials.gov
What's tested:MRI

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Regional brain/spine volumes
Measured over <3 months
+1 more outcome measured
Cerebral Palsy
Chronic Pain
4 sites across 1 states
Maryland4
  • Eric Chin, MD · PRINCIPAL_INVESTIGATOR · Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

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Eligibility criteria

Inclusion

Individual 8+ years of age
Diagnosis of cerebral palsy
Individual 8+ years of age
Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
Individual 8+ years of age
Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
Diagnosis of cerebral palsy
Clinical imaging demonstrating isolated periventricular white matter injury
Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury
Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI
Individual 8+ years of age
Adult subject able to indicate understanding and affirmative consent
Able to lie still in scanner for 1.5 hours and be able to have MRI

Exclusion

None
Clinically-significant neurologic or developmental diagnosis
None
Clinically-significant neurologic or developmental diagnosis
  • Regional brain/spine volumes<3 months

    Regional volumes will be measured using MR processing software

  • Diffusion scalars<3 months

    Diffusion scalars for tracts of interest including the posterior thalamic radiations as well as somatosensory association fibers and the spinothalamic tract