Exercise Training for Obesity, Diabetes, and Cardiovascular Disease
This study is looking at how exercise training affects blood vessel health in people with obesity and type 2 diabetes. Researchers want to understand how physical activity can improve the function of blood vessels, which is important because poor vessel function can lead to heart problems. You might be able to join if you are between 18 and 50 years old, have a BMI of 35 or higher, and have diabetes. The study involves 60 participants who will do aerobic exercise training. The main goal is to see how much your blood vessels can widen (flow-mediated dilation) after 12 weeks of exercise.
- Study design
- This interventional study plans to enroll 60 participants. It will examine the effects of exercise training on blood vessel function.
- What's involved
- Participants will engage in aerobic exercise training using a treadmill or bike for 12 weeks, three times per week, for 60 minutes per session.
- Compensation
- Not stated in the trial record.
- Follow-up
- Blood vessel function will be measured at 4 years after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Role of Adiposomes in Endothelial Dysfunction
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Abeer M Mohamed, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Illinois at Chicago
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Brachial artery flow-mediated dilation (percent vasodilation) in 60 obese diabetic subjects4 years
Brachial flow-mediated dilation will be measured using ultrasound Alpha 7. For recording, a linear probe will be positioned five centimeters above the left arm's antecubital fossa, and a 1-minute baseline imaging will be recorded. Then, a blood pressure cuff will be put around the right mid-forearm and inflated to 200 to 220 mmHg for 5 minutes. Following cuff deflation (reactive hyperemia), a video grabber will be used to record a 300-second video sequence at three frames per second for offline measurement. The greatest brachial artery diameter at baseline will be deducted from the largest mean values obtained following cuff deflation to determine relative flow mediated dilation