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Perturbation Training for Fall Reduction in Alzheimer's Disease

This study is looking at whether "perturbation training" can help people with Alzheimer's disease (AD) learn skills to prevent falls. Perturbation training involves experiencing repeated unexpected movements on a treadmill while wearing a safety harness. Researchers want to see if people with mild AD, aged 65 to 90, can learn these skills and keep them over time. The main goal is to measure how many falls happen in the lab after training, six months later. You must be able to walk and stand independently, and have a specific score on a cognitive test to join. The study's current status is unclear.

Study design
This interventional study plans to enroll 30 participants with Alzheimer's disease. One group will receive perturbation training, and another will not.
What's involved
Participants will attend a perturbation training session. Falls will be tracked immediately after training, and again three and six months later.
Compensation
Not stated in the trial record.
Follow-up
Daily-living falls will be tracked for six months after the training session.

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NCT05205980

Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)

Recruiting
NAAges 65–90InterventionalPrevention
Georgia State University
~30 participants
Updated 2026-02-04 on ClinicalTrials.gov
What's tested:Perturbation training

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Lab-induced faller rate
Measured over 6 months

Conditions

Alzheimer Disease

Explore related trials

Alzheimer's Disease

Where it's being run

1 sites across 1 states
Georgia1

Study leadership

  • Feng Yang, PhD · PRINCIPAL_INVESTIGATOR · Georgia State University

Who to contact

Feng Yang, PhD
[email protected]
404-413-8357
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants must be at least 65 years old;
Participants have a clinical diagnosis of probable AD;
Participants can read and understand English;
Participants must be able to walk independently at least 25 feet;
Participants must be able to stand independently for at least 30 seconds;
Participants must have a Montreal Cognitive Assessment score of 11-21 or Mini Mental Status Examination score between 18 and 23.

Exclusion

Individuals have ever experienced perturbation training;
Individuals have hypotension or uncontrolled hypertension;
Individuals exhibit osteoporosis;
Participants suffer from coexisting psychiatric disorders, or other neurological conditions, or injuries, etc.

What this trial measures

  • Lab-induced faller rate6 months

    The outcome of each perturbation trial will be determined as a fall if the peak load cell force exceeds 30% of the body weight. The load cell records the force applied to the human body by the safety harness system after a perturbation. The lab-induced faller rate will be calculated as the ratio of the number of fallers to the number of participants within each group.