Valbenazine for Trichotillomania (Hair-Pulling Disorder)

This study is testing valbenazine, an oral capsule, to see if it can help adults with trichotillomania (hair-pulling disorder). Participants will receive either valbenazine or a placebo (an inactive capsule that looks the same) for 12 weeks. After this, all participants will receive valbenazine for another 12 weeks. The study aims to find the best dose of valbenazine (either 40mg or 80mg) and measure how much hair-pulling symptoms improve using a special scale. You can join if you are an adult between 18 and 65 years old, in good health, and on a stable psychiatric medication regimen. The current recruitment status is unclear.

Study design
This is a double-blind, placebo-controlled study where participants are randomly assigned to receive either valbenazine or placebo. Approximately 20 participants will be enrolled.
What's involved
You would take an oral capsule daily for 24 weeks, with the first 12 weeks being either valbenazine or placebo, and the next 12 weeks being valbenazine. Your dose may be adjusted during the first few weeks.
Compensation
Not stated in the trial record.
Follow-up
You will have follow-up assessments at the end of week 26, which is two weeks after your last dose of valbenazine.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05207085

Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults

Recruiting
PHASE2Ages 18–65InterventionalTreatment
Yale University
~20 participants
Updated 2026-02-03 on ClinicalTrials.gov
What's tested:Valbenazine Oral CapsulePlacebo Oral capsule

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Massachusetts General Hospital Hairpulling Scale (MGH-HPS) from baseline to Week 12
Measured over baseline to week12
Trichotillomania (Hair-Pulling Disorder)
1 sites across 1 states
Connecticut1
  • Michael H. Bloch, MD · PRINCIPAL_INVESTIGATOR · Yale University

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  • Change in Massachusetts General Hospital Hairpulling Scale (MGH-HPS) from baseline to Week 12baseline to week12

    Massachusetts General Hospital Hairpulling Scale (MGH-HPS) scores range from 0-28 with 28 being the most severe. The lower the total score, the lower the severity level. This scale is given and measured once every 2 weeks for a total of 12 weeks.