Immune Responses to Gluten in Celiac Disease Study
This study is looking at how your body's immune system reacts after eating gluten. Researchers will give you a single dose of Gluten Powder to see how it affects your immune response. You might be able to join if you are between 2 and 101 years old, have been on a gluten-free diet for at least 4 weeks, and are willing to eat gluten for the study. If you have celiac disease, your diagnosis needs to be confirmed by blood tests or tissue samples. The main goal is to measure changes in a specific immune marker called interleukin-2 (IL-2) in your blood, 4 hours after you eat the gluten powder. The current status of this study is unclear, and it plans to enroll 400 participants.
- Study design
- This is an open-label study, meaning both you and the study staff will know what intervention you are receiving. It involves a single dose of gluten and plans to include 400 participants.
- What's involved
- You will provide a blood sample before and 4 hours after eating gluten powder.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your immune response will be measured at baseline and 4 hours after taking the gluten powder.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Immune Responses to Gluten
At a glance
Conditions
NCT05209568
Where you'd take part
This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Boston Children's Hospital
Boston, Massachusettsno site contact published
Children's Hospital Colorado
Aurora, Coloradono site contact published
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Jocelyn A Silvester, MD, PhD · PRINCIPAL_INVESTIGATOR · McMaster University
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- Change in serum interleukin-2 (IL-2) level from baseline to 4 hours after a single oral dose of glutenBaseline, 4 hours
To determine the change in serum IL-2 level from baseline after a single oral dose of gluten