MRI in High-Grade Glioma Patients Undergoing Chemoradiation
This study aims to understand how brain function changes after radiation treatment for high-grade glioma (a type of brain cancer). Researchers want to see if special scans (PET-MRI brain scans) and blood tests can predict who might experience changes in memory or attention after radiation. You would have PET-MRI scans, blood draws, and memory testing. Some participants may also have an optional lumbar puncture (spinal tap) to collect cerebrospinal fluid. The study will look at how many participants complete these tests and scans. You may be able to join if you are at least 18 years old, have high-grade glioma, and are expected to receive 6 weeks of chemoradiation. The study is currently unclear on its recruitment status and plans to enroll 16 participants.
- Study design
- This is an interventional study with no specified phase, planning to enroll 16 participants. It is not stated if it is randomized or blinded.
- What's involved
- You would have PET-MRI brain scans before radiation, 2-3 weeks into radiation, and 1 month after radiation. Blood draws are taken at the start, one month after radiation, and 3-4 months after radiation. Memory testing involves three 1-hour sessions.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for at least 4 months after radiation treatment to complete PET scans and cognitive testing.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
MRI in High-Grade Glioma Patients Undergoing Chemoradiation
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Christina Cramer, MD · PRINCIPAL_INVESTIGATOR · Wake Forest Baptist Comprehensive Cancer Center
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Number of Participants to Complete Two PET scansAt baseline and at 4 months post-treatment
Feasibility is defined as 70% of patients who complete two PET scans. This proportion and its 95% confidence interval will be calculated at 4 months
- Number of Participants to Complete Cognitive TestingAt baseline and at 4 months post-treatment
Using a customized abbreviated cognitive battery designed for brain tumor patients to measure a range of cognitive functions affected by cancer and radiation treatment including basic attention, information processing speed, language, learning and recent memory, executive functions (spanning verbal fluency, cognitive set-shifting, and abstract reasoning), and visual perceptual/spatial skills. Premorbid functioning (assessing cognitive reserve) will also be assessed via a single word reading test that is strongly associated with overall intellectual functioning. Most tests have multiple forms to allow for assessment at sequential time points. All tests have well-validated normative data and have been used previously with cancer patients. Fatigue, depression, anxiety, and quality of life will be evaluated simultaneously using standard and validated patient questionnaires