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NCT05214092

Cortical Contributions to FFR: Post-Op Outcomes

Enrolling by Invitation
NAAges 13–25InterventionalBasic science
University of Pittsburgh
~10 participants
Updated 2026-01-15 on ClinicalTrials.gov
What's tested:Speech sound stimulation

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pitch Decoding Accuracy
Measured over During sEEG-EEG recording sessions, up to 3 hours total
+5 more outcomes measured

Conditions

Language

Explore related trials

Heschl's Gyrus Lesion

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Taylor Abel, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Individuals 13-25 years old
Undergoing medically necessary surgical resection of Heschl's gyrus lesion
Monolingual English speakers
Receptive and expressive language within normal limits
Normal or corrected-to-normal visual acuity
Normal hearing acuity in each ear (as determined during an audiometric assessment)
Nonverbal IQ within normal limits
No history of autism spectrum disorder or attention-deficit hyperactivity disorder

Exclusion

Significant medical or neuropsychological impairment that would result in the patient being unable to participate in study activities
History of autism or ADHD

What this trial measures

  • Pitch Decoding AccuracyDuring sEEG-EEG recording sessions, up to 3 hours total

    Pitch decoding accuracy will be measured as a stimulus-to-response correlation between stimulus pitch (in Hz) and scalp-recorded frequency-following responses (FFR). Hidden Markov models (HMMs) will be used to decode stimulus identity information from recorded FFRs.

  • Frequency-Following Response MagnitudeDuring sEEG-EEG recording sessions, up to 3 hours total

    The frequency-following response magnitude will be measured by analyzing the time-domain averaged spectral peak of scalp-recorded FFRs.

  • Cortical Phase-Locking Limits of Frequency-Following ResponseDuring sEEG-EEG recording sessions, up to 3 hours total

    Phase-locking limits of FFRs will be measured by comparing phase coherence of stimulus waveforms and scalp-recorded FFRs. The phase-locking limit will be determined as a function of dependence on stimulus frequency.

  • Predictability Effects of Cortical Resection on Pitch Decoding AccuracyDuring follow-up research sessions, at least 6-months post-sEEG

    The predictability effects of cortical resection on pitch decoding accuracy will be measured via comparison of decoding accuracies obtained in Outcome 1 and values predicted by a previously created computational model of frequency-following response constrained by data from neurotypical participants.

  • Predictability Effects of Cortical Resection on Frequency-Following Response MagnitudeDuring follow-up research sessions, at least 6-months post-sEEG

    The predictability effects of cortical resection on frequency-following response magnitude will be measured via comparison of response magnitude measurements obtained in Outcome 3 and values predicted by a previously created computational model of frequency-following response constrained by data from neurotypical participants.

  • Predictability Effects of Cortical Resection on Phase-Locking Limits of Frequency-Following ResponseDuring follow-up research sessions, at least 6-months post-sEEG

    The predictability effects of cortical resection on phase-locking limits of the frequency-following response will be measured via comparison of phase-locking limits obtained in Outcome 3 and values predicted by a previously created computational model of frequency-following response constrained by data from neurotypical participants.