Observational Study of WTC Particulate Matter and Cardiorespiratory/Vascular Dysfunction

This study is looking at how exposure to World Trade Center (WTC) particulate matter (tiny particles) might lead to heart, lung, and blood vessel problems (cardiorespiratory and vascular dysfunction). Researchers are studying 100 FDNY rescue and recovery workers who were exposed to WTC particulate matter. The goal is to understand how this exposure affects your body by measuring specific markers in your blood, such as Heme Oxygenase-1 (HO-1), Glutathione, and Total Antioxidant Capacity (TAC). These measurements will be taken over a period of up to one year to see how they change. This is an observational study, meaning researchers will collect information without giving any specific treatments.

Study design
This is an observational study with a planned enrollment of 100 participants. It is not a treatment study, but rather aims to understand the effects of past WTC exposure.
What's involved
Participants will have their levels of Heme Oxygenase-1, Glutathione, and Total Antioxidant Capacity measured over a period of up to 365 days.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 365 days, based on the primary endpoint timeframes.

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NCT05215171

World Trade Center Particulate Matter Induced Cardiorespiratory and Vascular Dysfunction: a MultiOmic Approach (CaRVD)

Recruiting
Not specifiedAges 21–90Observational
NYU Langone Health
~100 participants
Updated 2026-02-04 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Levels of Heme Oxygenase-1 (HO-1)
Measured over up to Day 365
+7 more outcomes measured
Cardiorespiratory and Vascular Dysfunction
Obstructive Airway Disease
1 sites across 1 states
New York1
  • Anna Nolan, MD · PRINCIPAL_INVESTIGATOR · NYU Langone Health

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  • Levels of Heme Oxygenase-1 (HO-1)up to Day 365

    All serum will be thawed once and assayed for biomarkers

  • Levels of Glutathioneup to Day 365

    All serum will be thawed once and assayed for biomarkers

  • Levels of Total Antioxidant Capacity (TAC)up to Day 365

    All serum will be thawed once and assayed for biomarkers

  • Levels of Superoxide Dismutase (SOD)up to Day 365

    All serum will be thawed once and assayed for biomarkers

  • Levels of Macrophage inflammatory protein-2 (MIP-2)up to Day 365

    All serum will be thawed once and assayed for biomarkers

  • Levels of C-reactive protein (CRP)up to Day 365

    All serum will be thawed once and assayed for biomarkers

  • Levels of fractional exhaled nitric oxide (FeNO)up to Day 365

    FeNO will be quantified using NIOX VERO®

  • Score on St. George's Respiratory Questionnaire (SGRQ-C)up to Day 365

    SGRQ-C is designed to assess how one's breathing is troubling a participant and how it affects one's life. The questionnaire consists of 14 questions. The total score range is 0-54; the higher the score, the worse the chest trouble.