This study aims to understand the brain differences between laryngeal dystonia (a voice disorder where muscles spasm) and voice tremor (a shaky voice). Researchers will use brain imaging techniques like functional MRI, MEG (magnetoencephalography), and EEG (electroencephalography) to look for specific patterns in the brain. They will also use a laryngeal sensory block with topical bupivacaine (a numbing medicine) to see how blocking sensation in the voice box affects brain activity and voice function. The study is looking for 165 participants, including those with laryngeal dystonia or voice tremor, and healthy volunteers, aged 18 to 80. The main goal is to see how brain signals change in these conditions and how the bupivacaine treatment impacts voice function over five years.

Study design

This is an interventional study planning to enroll 165 participants. It will compare brain activity in individuals with laryngeal dystonia, voice tremor, and healthy controls.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The study will measure changes in brain signals and voice function over a period of five years.

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