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REMM-HIIT for COVID-19 Recovery

This study is testing a rehabilitation program called REmotely Monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT). This program uses remote monitoring and mobile health tools to provide tailored physical rehabilitation and coaching to help people recover after being critically ill with COVID-19. We are looking for 120 adults, aged 18 or older, who were hospitalized for COVID-19 and are able to walk. You must be discharged directly home from the hospital. The main goal is to see if REMM-HIIT improves your walking distance over 6 minutes, measured from when you start the program until 3 months later. The current recruitment status is unclear.

Study design
This is a multicenter, prospective, randomized controlled trial involving 120 participants.
What's involved
You will participate in a remotely monitored, mobile health-supported rehabilitation program and complete at least one exercise session. Your walking distance will be measured at the beginning and again at 3 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3 months after starting the program.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05218083

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Recruiting
NAAges 18+InterventionalTreatment
Duke University
~120 participants
Updated 2026-05-28 on ClinicalTrials.gov
What's tested:REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT)

At a glance

Recruiting sites
5 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in 6 minute walk distance
Measured over Baseline to 3 month follow-up

Conditions

COVID-19
Critical Illness
ICU Acquired Weakness
PICS
Cardiorespiratory Fitness

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COVID-19 Infection

Where it's being run

5 sites across 5 states
Alabama1
Kentucky1
North Carolina1
Ohio1
Tennessee1

Study leadership

  • Paul Wischmeyer, MD · PRINCIPAL_INVESTIGATOR · Duke Clinical Research Institute

Who to contact

Marjan Cobbaert, MPH
[email protected]
919-668-9740
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Primary diagnosis of COVID-19 requiring hospital admission
Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)
Able to ambulate with or without a gait aid prior to hospital discharge
Age ≥ 18 years

Exclusion

Hospital discharge \> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \> 60 days
Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)
Functional impairment resulting in inability to exercise at baseline
Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction
Any absolute contraindications to exercise, including but not limited to:
Recent (\< 5 days) acute primary cardiac event
Unstable Angina
Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise
Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure
Symptomatic aortic stenosis
Uncontrolled symptomatic heart failure
Acute myocarditis or pericarditis
Suspected or known dissecting aneurysm
Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \< 60 mmHg on 2 consecutive readings within 1 minute)
High risk for non-adherence as determined by screening evaluation
Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study
Pregnant

What this trial measures

  • Change in 6 minute walk distanceBaseline to 3 month follow-up

    distance walked in m