OCD Treatment with Cognitive Bias Modification

This study is looking at a new approach called Cognitive Bias Modification for Interpretation (CBM-I) for adults with Obsessive-Compulsive Disorder (OCD). CBM-I is a digital program that helps change how people interpret ambiguous situations, aiming to reduce biased thinking often seen in anxiety. You would be recruited from an OCD treatment program and randomly assigned to either receive up to 12 sessions of CBM-I or up to 12 sessions of psychoeducation (education about anxiety and treatments). The researchers want to see if CBM-I is practical, acceptable, and helps improve OCD symptoms, measured by changes in your Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score over 8 weeks. To join, you need to be an adult patient at the OCD Institute with a primary OCD diagnosis and be able to complete a 20-minute computer task.

Study design
This is a randomized controlled trial with 106 planned participants. You would be randomly assigned to one of two groups.
What's involved
You would participate in up to 12 sessions of either CBM-I or psychoeducation. Your OCD symptoms would be measured at the start, at 4 weeks, and at 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be followed for 8 weeks after the start of the study.

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NCT05224414

Interpretation Bias as a Mechanism of Treatment Response in OCD

Recruiting
NAAges 18+InterventionalBasic science
Mclean Hospital
~106 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:Cognitive bias modification for interpretation biasPsychoeducation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Average Score on Yale-Brown Obsessive Compulsive Scale
Measured over Weeks 0, 4, and 8
Obsessive-Compulsive Disorder
1 sites across 1 states
Massachusetts1

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Eligibility criteria

Inclusion

1\) OCD Institute patients
2\) adults (\> 18 years old)
3\) able to complete a computer task for 20 minutes
4\) consent to main OCD Institute study protocol
5\) primary diagnosis of OCD (as measured by a score of \>16 on the Y-BOCS and a clinical diagnosis of OCD by their treatment team
6\) score of \>131 on the Obsessive Beliefs Questionnaire-44 at admission \[which is 1 SD above the mean score of the non-clinical sample reported in the original validation paper by the Obsessive Compulsive Cognitions Working Group (2005)\]

Exclusion

1\) Currently experiencing acute symptoms of psychosis
2\) Psychotic disorder diagnosis
  • Change in Average Score on Yale-Brown Obsessive Compulsive ScaleWeeks 0, 4, and 8

    Interviewer-rated measure of OCD symptoms. It is 19 items, with only items 1-10 scored (from 0-4). Total scores range from 0-40, with higher scores reflecting greater severity.