Single Dose Amikacin for Uncomplicated Cystitis in the ED: A Feasibility Study

{ "Single Dose Amikacin for Uncomplicated Cystitis", "This study is looking at whether a single dose of amikacin, an antibiotic, can effectively treat uncomplicated cystitis (a bladder infection) in women seen in the emergency department. You might be eligible if you are a female emergency patient, at least 14 years old, with an uncomplicated urinary tract infection (UTI) and a positive nitrite test in your urine. The main goal is to see if your UTI symptoms improve within 3 days (72 hours) after receiving the amikacin. This study aims to show that giving a single shot of amikacin in the emergency department is a practical way to treat these UTIs, potentially saving you a trip to the pharmacy and days of taking pills.", "design": "This is an observational study planning to enroll 75 female emergency department patients with uncomplicated cystitis. You would receive a single dose of amikacin.", "commitments": "You would receive a single shot of amikacin (either into a vein or muscle) in the emergency department. The study will collect information about your age, medical history, medications, allergies, symptoms, and urinalysis results at the time of enrollment.", "compensation": "Not stated in the trial record.", "follow_up": "The study will check for resolution of your UTI symptoms at 3 days (72 hours) after treatment.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05227937

Single Dose Amikacin for Uncomplicated Cystitis in the ED: A Feasibility Study

Recruiting
Not specifiedAges 14+Observational
Antonios Likourezos
~75 participants
Updated 2026-03-04 on ClinicalTrials.gov
What's tested:Amikacin

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Resolution of Urinary Tract Infection Symptoms
Measured over 3 days (72 hours)
Urinary Tract Infections
1 sites across 1 states
New York1
  • Reuben Strayer, MD · PRINCIPAL_INVESTIGATOR · Maimonides Medical Center

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Eligibility criteria

Inclusion

female emergency medicine patients
≥14 years of age
uncomplicated urinary tract infection
a primary urinary complaint and nitrite-positive urine.

Exclusion

pregnancy
abnormal genitourinary tract
recent urinary tract instrumentation
immunosuppression
CrCl \< 25 mL/min
evidence of pyelonephritis or sepsis
any antibiotic treatment within 30 days
not available for phone follow-up in 3, 7, and 30 days
requires admission to the hospital
abnormal mental status.
  • Resolution of Urinary Tract Infection Symptoms3 days (72 hours)

    \>80% of patients treated with amikacin will have resolution of urinary tract infection symptoms.