Investigating Neuromuscular Ultrasound

This study is looking at new ways to use ultrasound (sound waves) to understand nerves and muscles better. Current methods are good, but researchers want to improve how we observe these parts of the body. The study aims to collect normal measurements of diaphragm (breathing muscle) movement and nerve/muscle characteristics using ultrasound in healthy people. This information will help establish a baseline for comparison with individuals who have conditions like muscular dystrophy, peripheral neuropathy (nerve damage), or motor neuron disorders. You can join if you are a healthy adult, aged 18 to 110, with no history of stroke, nerve/muscle disorders, or spine surgery. A smaller group of adults with neuromuscular disorders will also be evaluated. The goal is to see if these ultrasound techniques can provide reliable information for future clinical trials.

Study design
This is an observational study with a planned enrollment of 150 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will be screened with a medical record review. The study involves ultrasound imaging of nerves and muscles, including measurements during quiet and deep breathing, and sniff testing.
Compensation
Not stated in the trial record.
Follow-up
Measurements for the primary endpoints are ongoing, but the duration of individual participant follow-up is not specified.

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NCT05237973

Investigational Use of Neuromuscular Ultrasound

Recruiting
Not specifiedAges 18+Observational
National Institute of Neurological Disorders and Stroke (NINDS)
~150 participants
Updated 2026-08-18 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To collect normal values of M-mode diaphragm imaging during quiet and deep breathing and voluntary sniff testing in a population of health controls to establish normal values.
Measured over ongoing
+1 more outcome measured
Muscular Dystrophy
Peripheral Neuropathy
Motor Neuron Disorder
Normal Physiology
1 sites across 1 states
Maryland1
  • Tanya J Lehky, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Neurological Disorders and Stroke (NINDS)

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  • To collect normal values of M-mode diaphragm imaging during quiet and deep breathing and voluntary sniff testing in a population of health controls to establish normal values.ongoing

    Normative values for M-mode imaging of the diaphragm in a population of healthy controls.

  • To acquire normative values for B-mode imaging of nerves (fascicle count) and muscles (quantitative echotexture measurement) and shear wave elastography data on muscle and nerve stiffness/speed of sound in a population of healthy volunteers.ongoing

    Normative values for muscle and nerve shear wave elastography in a population of normal volunteers Normative values for nerve fascicular count in a population of normal volunteers