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Brain Stimulation for Depression in Epilepsy Patients

This study is looking at how brain stimulation might help people with Major Depressive Disorder (severe depression). Researchers will use brain stimulation (a procedure where small electrical currents are sent to specific brain areas) after collecting information about seizures. They want to understand how certain brain areas involved in decision-making and mood regulation respond to this stimulation. You might be able to join if you are an adult between 18 and 80 years old and meet the clinical criteria for epilepsy patient recruitment for invasive monitoring. The main goal is to see how brain stimulation affects your performance on a gambling task on Day 1. The study status is currently unclear.

Study design
This is an interventional study with a planned enrollment of 10 participants. It is not specified if it's randomized or blinded.
What's involved
You will complete a decision-making task, and some participants will do it a second time with electrical stimulation. Your depression status will also be assessed using questionnaires.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, a gambling task, is measured on Day 1. Further follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05239780

Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients

Recruiting
NAAges 18–80InterventionalTreatment
Icahn School of Medicine at Mount Sinai
~10 participants
Updated 2025-09-25 on ClinicalTrials.gov
What's tested:Brain stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Gambling Task
Measured over Day 1

Conditions

Major Depressive Disorder

Explore related trials

Seizure DisorderUnipolar Depression

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Ignacio Saez, Ph.D. · PRINCIPAL_INVESTIGATOR · Icahn School of Medicine at Mount Sinai

Who to contact

Lizbeth Nunez Martinez
[email protected]
(661) 772-6200
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Adults over 80 years of age will be excluded as per concerns of cognitive decline.
Children under 18 will be excluded from the study since the maturation of frontal lobes continues through adolescence and significant differences in frontal lobe functioning between children younger than 18 and adults are often observed.

What this trial measures

  • Gambling TaskDay 1

    Risk attitudes will be evaluated behaviorally. Patients' behavior will in examined in experimental task (a gambling task) to determine overall proportion of risky choices (gambles) and indifference points (expected gamble value at which the patient is equally likely to choose a gamble or a safe bet). Score from 0%-100%, with higher percent indicating choosing the risky gamble more often.